Citation: Qi Zhang, Ziyu Liu, Hongxia Tan, Jun Tong, Dazhen Xu. Research Progress on Direct Synthesis of β-Hydroxy Sulfones via Difunctionalization of Olefins[J]. University Chemistry, ;2025, 40(11): 199-209. doi: 10.12461/PKU.DXHX202412064 shu

Research Progress on Direct Synthesis of β-Hydroxy Sulfones via Difunctionalization of Olefins

National Engineering Research Center of Pesticide, College of Chemistry, Nankai University, Tianjin 300071, China

Corresponding author: Jun Tong, Dazhen Xu,
Received Date: 11 December 2024
Revised Date: 9 May 2025

β-Hydroxy sulfone is a prevalent structural motif in many biologically active molecules, and provide useful building blocks in organic synthesis. Recent years have witnessed growing interest among chemists in the direct construction of β-hydroxy sulfones through olefin difunctionalization. This paper first introduces some representative compounds containing β-hydroxy sulfone moiety, then reviews the progress for the construction of β-hydroxy sulfones via direct difunctionalization of olefins. At the end, future development prospects in this field are proposed.
- Radical,
- Oxidation,
- Sulfonation,
- Olefin
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