Citation: Yuanyuan Ping, Wangqing Kong. 光催化碳氢键官能团化合成1-苯基-1,2-乙二醇[J]. University Chemistry, ;2025, 40(6): 238-247. doi: 10.12461/PKU.DXHX202408092 shu

光催化碳氢键官能团化合成1-苯基-1,2-乙二醇

Yuanyuan Ping ¹ ,
Wangqing Kong ^1,2

1.
The Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, China;
2.
National Demonstration Center for Experimental Chemistry Education (Wuhan University), Wuhan 430072, China

Received Date: 24 August 2024
Revised Date: 14 October 2024

惰性碳氢键的直接官能团化是合成化学领域的前沿挑战之一，被认为是有机合成的“圣杯”。近年来，光氢原子转移(HAT)已发展成为活化惰性碳氢键的重要工具之一。我们以大宗化学品乙二醇与商业化可得的溴苯为原料，通过光氢原子转移/镍协同催化实现了1-芳基-1,2-乙二醇的高效合成。本实验综合性强，操作简便安全，涵盖无水无氧操作、薄层色谱法与快速柱层析操作、气相色谱-质谱联用以及核磁共振检测与解析等多项实验操作。此外，该实验条件温和，原料廉价易得，操作简单且不需要复杂的设备，既能让学生了解有机化学的前沿进展，激发学生学习化学的兴趣和热情，调动学生学习的积极性和主动性，还能使学生的实验技能得到充分锻炼，培养学生的科学素养和探索未知的精神，具有重大的应用价值与教学价值。
- Photohydrogen atom transfer,
- Nickel catalysis,
- Radical chemistry,
- 1-Phenylethane-1,2-diol,
- Organic chemistry experiment
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