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Citation: Aiyi Xin, Jiawei Li, Xinyang Ran, Chuanjiang Fu, Zhiguo Wang. Collaborative Science and Education Based Experimental Design in Organic Chemistry: A Case Study of the Nucleophilic Substitution Reaction of 2-Hydroxymethyl-4,6-Di-Tert-Butylphenol[J]. University Chemistry, ;2025, 40(5): 366-375. doi: 10.12461/PKU.DXHX202407031 shu

Collaborative Science and Education Based Experimental Design in Organic Chemistry: A Case Study of the Nucleophilic Substitution Reaction of 2-Hydroxymethyl-4,6-Di-Tert-Butylphenol

School of Chemistry and Chemical Engineering, Mianyang Normal University, Mianyang 621000, Sichuan Province, China

Corresponding author: Zhiguo Wang, wangzhiguo224865@163.com
Received Date: 3 July 2024
Revised Date: 11 November 2024

The experimental phenomena observed in gas-liquid-solid reactions serve to stimulate students’ interest in learning. The intricate connections between gas generation, drying, and tail gas treatment equipment encourage students to adopt a mindset of understanding the sequence and significance of processes. Through the separation, purification, and characterization of products, students develop comprehensive skills in organic synthesis. Standardizing the use of concentrated sulfuric acid and managing hazardous gas treatments enhance students’ awareness of emergency protocols and environmental responsibility. Finally, by extending the experimental focus to a series of related reactions, students are guided to transition from theoretical knowledge to practical application.
- Integration of science and education,
- Organic chemistry,
- Halogenated hydrocarbon,
- Nucleophilic substitution
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