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Citation: Shuhui Li, Rongxiuyuan Huang, Yingming Pan. Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment[J]. University Chemistry, ;2025, 40(5): 357-365. doi: 10.12461/PKU.DXHX202407028 shu

Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, Guangxi, China

Corresponding author: Yingming Pan, panym@mailbox.gxnu.edu.cn
Received Date: 2 July 2024
Revised Date: 11 November 2024

This experiment employs an electrochemical synthesis method to produce 2,5-diphenyl-1,3,4-oxadiazole from benzoylhydrazine. The structure of the synthesized product is identified and characterized using analytical techniques, including NMR, infrared spectroscopy, and melting point determination. In comparison to traditional organic synthesis methods, the electrochemical approach aligns with green chemistry principles, offering advantages such as simplicity, mild reaction conditions, and high yield. This experiment encourages students, who have mastered fundamental organic laboratory techniques, to explore cutting-edge electrochemical synthesis methods and gain insights into the application of electrochemistry in organic synthesis. Additionally, it fosters students’ interest in scientific research and innovative thinking, thereby enriching the content of basic organic chemistry education.
- Electrochemistry,
- 2,5-Diphenyl-1,3,4-oxadiazole,
- Chemical experimental teaching,
- Organic synthesis
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