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Citation: Zhou Fang, Zhihao Zhang, Weihan Jiang, Kin Shing Chan. Warfarin: From Poison to Cure, the Remarkable Journey of a Molecule[J]. University Chemistry, ;2025, 40(4): 326-330. doi: 10.12461/PKU.DXHX202406038 shu

Warfarin: From Poison to Cure, the Remarkable Journey of a Molecule

1.
Anbang Academy, College of First-Year Students, Nanjing University, Nanjing 210023, China;
2.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Received Date: 11 June 2024
Revised Date: 12 August 2024

Originating from moldy sweet clover and developed in a biochemical laboratory, warfarin was initially deployed as a potent rodenticide. However, its journey into the medical field was met with skepticism and opposition, largely due to its reputation as a poison and circulating rumors. Scientists eventually uncovered warfarin’s anticoagulant mechanism and demonstrated the benefits of its use in anticoagulation therapy for patients. Since then, warfarin and its derivatives have become key agents in both anticoagulant treatment and rodent control.
- Anticoagulant,
- Dicoumarol,
- Vitamin K,
- Vitamin K epoxide reductase
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