Home

Citation: Yiming Liang, Ziyan Pan, Kin Shing Chan. One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions[J]. University Chemistry, ;2025, 40(4): 322-325. doi: 10.12461/PKU.DXHX202406016 shu

One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions

1.
Anbang Academy, Nanjing University, Nanjing 210023, China;
2.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Received Date: 11 June 2024
Revised Date: 2 July 2024

In the “human body” factory, the director of the hepatocyte workshop, nicknamed “Xiaodeng”, manages ethanol metabolism to maintain stability. However, with the onset of diseases like diabetes and insomnia, the central nervous system introduces foreign aids such as sedatives and antihypertensive drugs. Xiaodeng inadvertently overlooks the potential disulfiram-like reaction between medications and aldehyde dehydrogenase. In an unfortunate incident, a conflict between cephalosporin drugs and ethanol metabolism inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and ensuing chaos. Recognizing the oversight, Xiaodeng strengthens safety measures and instructs workers to exercise caution when using medications. Although the crisis is contained, this experience underscores the hepatocytes’ enhanced sense of responsibility and mission. We should learn from this and prioritize life, avoiding unnecessary risks such as excessive alcohol consumption. Let us unite in safeguarding this miraculous factory to ensure its safety and prosperity.
- Disulfiram-like reaction,
- Alcohol metabolism,
- Drug-alcohol interactions
1. [1]
  Hawkins, R. D.; Kalant, H. Pharmacol. Rev. 1972, 24, 67.
2. [2]
  De Sousa, A. Disulfiram: Pharmacology and Mechanism of Action; Springer: Singapore, 2019; pp. 9–20.
3. [3]
  Marx, J.; Walls, R.; Hockberger, R. Rosen’s Emergency Medicine: Concepts and Clinical Practice, 8th ed.; Elsevier Health Sciences: Philadelphia, PA, USA, 2013; pp. 2395–2399.
4. [4]
  Williams, S. H. Am. Fam. Physician 2005, 72, 1775.
5. [5]
  Vallari, R. C.; Pietruszko, R. Science 1982, 216, 637.
6. [6]
  Veverka, K. A.; Johnson, K. L.; Mays, D. C.; Lipsky, J. J.; Naylor, S. Biochem. Pharmacol. 1997, 53, 511.
7. [7]
  Stork, C. M. Goldfrank’s Toxicologic Emergencies; McGraw-Hill: New York, NY, USA, 2006; pp. 847–848.
8. [8]
  Mergenhagen, K. A.; Wattengel, B. A.; Skelly, M. K.; Clark, C. M.; Russo, T. A. Antimicrob. Agents Chemother. 2020, 64, e02167.
9. [9]
  Ghosh, A.; Mahintamani, T.; Balhara, Y. P. S.; Roub, F. E.; Basu, D.; Bn, S.; Mattoo, S. K.; Mishra, E.; Sharma, B. Alcohol. Alcohol. (Oxford, U. K.) 2021, 56, 42.
1. [1]
  Xueting Cao , Shuangshuang Cha , Ming Gong . 电催化反应中的界面双电层：理论、表征与应用. Acta Physico-Chimica Sinica, 2025, 41(5): 100041-. doi: 10.1016/j.actphy.2024.100041
2. [2]
  Xuzhen Wang , Xinkui Wang , Dongxu Tian , Wei Liu . Enhancing the Comprehensive Quality and Innovation Abilities of Graduate Students through a “Student-Centered, Dual Integration and Dual Drive” Teaching Model: A Case Study in the Course of Chemical Reaction Kinetics. University Chemistry, 2024, 39(6): 160-165. doi: 10.3866/PKU.DXHX202401074
3. [3]
  Hongyao Li , Youyan Liu , Luwei Dai , Min Yang , Qihui Wang . The Blessing of Indium Sulfide：Confronting the Narrow Path with Uric Acid. University Chemistry, 2024, 39(5): 325-335. doi: 10.3866/PKU.DXHX202311104
4. [4]
  Jinyao Du , Xingchao Zang , Ningning Xu , Yongjun Liu , Weisi Guo . Electrochemical Thiocyanation of 4-Bromoethylbenzene. University Chemistry, 2024, 39(6): 312-317. doi: 10.3866/PKU.DXHX202310039
5. [5]
  Peng Zhan . Practice and Reflection in Training Medicinal Chemistry Graduate Students. University Chemistry, 2024, 39(6): 112-121. doi: 10.3866/PKU.DXHX202402022
6. [6]
  Wei Gao , Jinyue Yang , Wenwei Zhang . Practice and Exploration of Promoting the “Double Reduction” Work with Popular Science Resources in Universities. University Chemistry, 2024, 39(9): 385-391. doi: 10.3866/PKU.DXHX202311008
7. [7]
  Ziheng Zhuang , Xiao Xu , Kin Shing Chan . Superdrugs for Superbugs. University Chemistry, 2024, 39(9): 128-133. doi: 10.3866/PKU.DXHX202309040
8. [8]
  Yingchun ZHANG , Yiwei SHI , Ruijie YANG , Xin WANG , Zhiguo SONG , Min WANG . Dual ligands manganese complexes based on benzene sulfonic acid and 2, 2′-bipyridine: Structure and catalytic properties and mechanism in Mannich reaction. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1501-1510. doi: 10.11862/CJIC.20240078
9. [9]
  Danqing Wu , Jiajun Liu , Tianyu Li , Dazhen Xu , Zhiwei Miao . Research Progress on the Simultaneous Construction of C—O and C—X Bonds via 1,2-Difunctionalization of Olefins through Radical Pathways. University Chemistry, 2024, 39(11): 146-157. doi: 10.12461/PKU.DXHX202403087
10. [10]
  Feiya Cao , Qixin Wang , Pu Li , Zhirong Xing , Ziyu Song , Heng Zhang , Zhibin Zhou , Wenfang Feng . Magnesium-Ion Conducting Electrolyte Based on Grignard Reaction: Synthesis and Properties. University Chemistry, 2024, 39(3): 359-368. doi: 10.3866/PKU.DXHX202308094
11. [11]
  Yue Zhao , Yanfei Li , Tao Xiong . Copper Hydride-Catalyzed Nucleophilic Additions of Unsaturated Hydrocarbons to Aldehydes and Ketones. University Chemistry, 2024, 39(4): 280-285. doi: 10.3866/PKU.DXHX202309001
12. [12]
  Hong Lu , Yidie Zhai , Xingxing Cheng , Yujia Gao , Qing Wei , Hao Wei . Advancements and Expansions in the Proline-Catalyzed Asymmetric Aldol Reaction. University Chemistry, 2024, 39(5): 154-162. doi: 10.3866/PKU.DXHX202310074
13. [13]
  Aili Feng , Xin Lu , Peng Liu , Dongju Zhang . Computational Chemistry Study of Acid-Catalyzed Esterification Reactions between Carboxylic Acids and Alcohols. University Chemistry, 2025, 40(3): 92-99. doi: 10.12461/PKU.DXHX202405072
14. [14]
  Weina Wang , Lixia Feng , Fengyi Liu , Wenliang Wang . Computational Chemistry Experiments in Facilitating the Study of Organic Reaction Mechanism: A Case Study of Electrophilic Addition of HCl to Asymmetric Alkenes. University Chemistry, 2025, 40(3): 206-214. doi: 10.12461/PKU.DXHX202407022
15. [15]
  Weihan Zhang , Menglu Wang , Ankang Jia , Wei Deng , Shuxing Bai . 表面硫物种对钯-硫纳米片加氢性能的影响. Acta Physico-Chimica Sinica, 2024, 40(11): 2309043-. doi: 10.3866/PKU.WHXB202309043
16. [16]
  Jiali Lin , Shuting Wu , Cheng Zheng , Zian Lin , Qiaohua Wei , Shoutian Zheng . Construction and Practice of National Chemical Experiment Teaching Demonstration Center in Local Universities under the Background of “Double First-Class”. University Chemistry, 2024, 39(7): 129-139. doi: 10.12461/PKU.DXHX202405043
17. [17]
  Jiaqi AN , Yunle LIU , Jianxuan SHANG , Yan GUO , Ce LIU , Fanlong ZENG , Anyang LI , Wenyuan WANG . Reactivity of extremely bulky silylaminogermylene chloride and bonding analysis of a cubic tetragermylene. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1511-1518. doi: 10.11862/CJIC.20240072
18. [18]
  Ling Fan , Meili Pang , Yeyun Zhang , Yanmei Wang , Zhenfeng Shang . Quantum Chemistry Calculation Research on the Diels-Alder Reaction of Anthracene and Maleic Anhydride: Introduction to a Computational Chemistry Experiment. University Chemistry, 2024, 39(4): 133-139. doi: 10.3866/PKU.DXHX202309024
19. [19]
  Haiying Wei , Daqing Yang , Mingtao Run , Guoyan Huo . Examination and Analysis on Rationality of Experimental Design: Based on Reaction of Potassium Permanganate with Potassium Bormide. University Chemistry, 2024, 39(10): 283-288. doi: 10.12461/PKU.DXHX202404068
20. [20]
  Jiaxun Wu , Mingde Li , Li Dang . The R eaction of Metal Selenium Complexes with Olefins as a Tutorial Case Study for Analyzing Molecular Orbital Interaction Modes. University Chemistry, 2025, 40(3): 108-115. doi: 10.12461/PKU.DXHX202405098

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(52)
HTML views(9)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Address：Zhongguancun North First Street 2,100190 Beijing, PR China Tel: +86-010-82449177-888

DownLoad: Full-Size Img PowerPoint

Return