Citation: Yiming Liang, Ziyan Pan, Kin Shing Chan. One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions[J]. University Chemistry, ;2025, 40(4): 322-325. doi: 10.12461/PKU.DXHX202406016 shu

One Drink, Two Tears in the Central Nervous System: The Perils of Disulfiram-Like Reactions

1.
Anbang Academy, Nanjing University, Nanjing 210023, China;
2.
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Received Date: 11 June 2024
Revised Date: 2 July 2024

In the “human body” factory, the director of the hepatocyte workshop, nicknamed “Xiaodeng”, manages ethanol metabolism to maintain stability. However, with the onset of diseases like diabetes and insomnia, the central nervous system introduces foreign aids such as sedatives and antihypertensive drugs. Xiaodeng inadvertently overlooks the potential disulfiram-like reaction between medications and aldehyde dehydrogenase. In an unfortunate incident, a conflict between cephalosporin drugs and ethanol metabolism inhibits acetaldehyde dehydrogenase, leading to acetaldehyde accumulation and ensuing chaos. Recognizing the oversight, Xiaodeng strengthens safety measures and instructs workers to exercise caution when using medications. Although the crisis is contained, this experience underscores the hepatocytes’ enhanced sense of responsibility and mission. We should learn from this and prioritize life, avoiding unnecessary risks such as excessive alcohol consumption. Let us unite in safeguarding this miraculous factory to ensure its safety and prosperity.
- Disulfiram-like reaction,
- Alcohol metabolism,
- Drug-alcohol interactions
1. [1]
  Hawkins, R. D.; Kalant, H. Pharmacol. Rev. 1972, 24, 67.
2. [2]
  De Sousa, A. Disulfiram: Pharmacology and Mechanism of Action; Springer: Singapore, 2019; pp. 9–20.
3. [3]
  Marx, J.; Walls, R.; Hockberger, R. Rosen’s Emergency Medicine: Concepts and Clinical Practice, 8th ed.; Elsevier Health Sciences: Philadelphia, PA, USA, 2013; pp. 2395–2399.
4. [4]
  Williams, S. H. Am. Fam. Physician 2005, 72, 1775.
5. [5]
  Vallari, R. C.; Pietruszko, R. Science 1982, 216, 637.
6. [6]
  Veverka, K. A.; Johnson, K. L.; Mays, D. C.; Lipsky, J. J.; Naylor, S. Biochem. Pharmacol. 1997, 53, 511.
7. [7]
  Stork, C. M. Goldfrank’s Toxicologic Emergencies; McGraw-Hill: New York, NY, USA, 2006; pp. 847–848.
8. [8]
  Mergenhagen, K. A.; Wattengel, B. A.; Skelly, M. K.; Clark, C. M.; Russo, T. A. Antimicrob. Agents Chemother. 2020, 64, e02167.
9. [9]
  Ghosh, A.; Mahintamani, T.; Balhara, Y. P. S.; Roub, F. E.; Basu, D.; Bn, S.; Mattoo, S. K.; Mishra, E.; Sharma, B. Alcohol. Alcohol. (Oxford, U. K.) 2021, 56, 42.
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沈阳化工大学材料科学与工程学院沈阳 110142