Citation: Lina Feng,  Guoyu Jiang,  Xiaoxia Jian,  Jianguo Wang. Application of Organic Radical Materials in Biomedicine[J]. University Chemistry, ;2025, 40(4): 253-260. doi: 10.12461/PKU.DXHX202405171 shu

Application of Organic Radical Materials in Biomedicine

  • Received Date: 27 May 2024
    Revised Date: 6 August 2024

  • Incorporating cutting-edge scientific examples into classroom teaching not only clarifies the practical value of fundamental research but also sparks students’ curiosity and fosters their enthusiasm for exploring advanced topics. Radical chemistry, a critical area of organic chemistry, is known for its high reactivity, complex mechanisms, and diverse products, making it both a key and challenging topic in organic chemistry education. In recent years, organic radicals, with their unique narrow-bandgap structural properties, have garnered significant attention in biomedical research, resulting in breakthroughs in diagnostics and treatment. However, as chemical species with unpaired electrons, radicals often exhibit kinetic and thermodynamic instability, which constrains their broader practical use. This article discusses the structural types and synthesis strategies for stabilizing organic radicals and explores their potential applications in precision biomedical diagnostics and photo-triggered therapies. Integrating the latest research on radicals into classroom instruction enhances students’ comprehension and expertise in this field.
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    1. [1]

      Cui, Z.; Abdurahman, A.; Ai, X.; Li, F. CCS Chem. 2020, 2 (4), 1129.

    2. [2]

      Chen, Z. X.; Li, Y.; Huang, F. Chem 2021, 7 (2), 288.

    3. [3]

      Morita, Y.; Murata, T.; Ueda, A.; Yamada, C.; Kanzaki, Y.; Shiomi, D.; Sato, K.; Takui, T. Bull. Chem. Soc. Jpn. 2018, 91 (6), 922.

    4. [4]

      Wang, X.; Zhang, Z.; Song, Y.; Su, Y.; Wang, X. Chem. Commun. 2015, 51 (59), 11822.

    5. [5]

      Kong, S.; Yang, L.; Sun, Q.; Wang, T.; Pei, R.; Zhao, Y.; Wang, W.; Zhao, Y.; Cui, H.; Gu, X. Angew. Chem. Int. Ed. 2024, 63 (19), e202400913.

    6. [6]

      Ji, L.; Friedrich, A.; Krummenacher, I.; Eichhorn, A.; Braunschweig, H.; Moos, M.; Hahn, S.; Geyer, F. L.; Tverskoy, O.; Han, J.; et al. J. Am. Chem. Soc. 2017, 139 (44), 15968.

    7. [7]

      Wang, H.; Xue, K.-F.; Yang, Y.; Hu, H.; Xu, J.-F.; Zhang, X. J. Am. Chem. Soc. 2022, 144 (5), 2360.

    8. [8]

      Nguyen, H. V. T.; Chen, Q.; Paletta, J. T.; Harvey, P.; Jiang, Y.; Zhang, H.; Boska, M. D.; Ottaviani, M. F.; Jasanoff, A.; Rajca, A.; et al. ACS Cent. Sci. 2017, 3 (7), 800.

    9. [9]

      Togashi, H.; Aoyama, M.; Oikawa, K. Magn. Reson. Med. 2015, 75 (3), 1375.

    10. [10]

      Zhou, Z.; Yang, K.; He, L.; Wang, W.; Lai, W.; Yang, Y.; Dong, Y.; Xie, S.; Yuan, L.; Zeng, Z. J. Am. Chem. Soc. 2024, 146 (10), 6763.

    11. [11]

      Zheng, L.; Zhu, W.; Zhou, Z.; Liu, K.; Gao, M.; Tang, B. Z. Mater. Horiz. 2021, 8 (11), 3082.

    12. [12]

      Cui, X.; Lu, G.; Dong, S.; Li, S.; Xiao, Y.; Zhang, J.; Liu, Y.; Meng, X.; Li, F. Mater. Horiz. 2021, 8 (2), 571.

    13. [13]

      Gao, H.; Zhi, X.; Wu, F.; Zhao, Y.; Cai, F.; Li, P.; Shen, Z. Angew. Chem. Int. Ed. 2023, 62 (40), e202309208.

    14. [14]

      Li, X.; Zhang, D.; Yin, C.; Lu, G.; Wan, Y.; Huang, Z.; Tan, J.; Li, S.; Luo, J.; Lee, C.-S. ACS Appl. Mater. Interfaces 2021, 13 (14), 15983.

  • 加载中
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