Citation: Zheqi Wang, Yawen Lin, Shunliu Deng, Huijun Zhang, Jinmei Zhou. Antiviral Strategies: A Brief Review of the Development History of Small Molecule Antiviral Drugs[J]. University Chemistry, ;2024, 39(9): 85-93. doi: 10.12461/PKU.DXHX202403108 shu

Antiviral Strategies: A Brief Review of the Development History of Small Molecule Antiviral Drugs

Zheqi Wang ^1,2 ,
Yawen Lin ³ ,
Shunliu Deng ^1,2 ,
Huijun Zhang ^1,2 ,
Jinmei Zhou ^1,2

1.
College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian Province, China;
2.
National Demonstration Center for Experimental Chemistry Education, Xiamen University, Xiamen 361005, Fujian Province, China;
3.
School of Pharmaceutical Science, Xiamen University, Xiamen 361102, Fujian Province, China

Received Date: 29 March 2024
Revised Date: 23 May 2024

Viruses have long been a significant threat to human survival and development, with recent events such as the COVID-19 pandemic vividly highlighting their dangers. Small molecule drugs have historically played a crucial role in humanity’s efforts to combat diseases. In the fight against viruses, humans have developed a range of strategies, with small molecule antiviral drugs occupying a pivotal position. Drawing inspiration from the classic “Thirty-Six Stratagems” of ancient Chinese military tactics, this article provides a concise overview of the developmental history of small molecule antiviral drugs, focusing on the design principles and mechanisms of representative drugs like idoxuridine, saquinavir, and oseltamivir. Furthermore, the article provides insights into future directions for small molecule antiviral drugs and antiviral methodologies.
- Antivirus,
- Small molecule drugs,
- Thirty-Six stratagems
1. [1]
2. [2]
  Voigt, E. A.; Kennedy, R. B.; Poland, G. A. Expert Rev. Vaccines 2016, 15, 1197.
3. [3]
  Baer, G. M. The Natural History of Rabies, 2nd ed.; Elsevier Science CA: New York, NY, USA, 2007; pp. 11–19.
4. [4]
  Isaacs, A.; Lindenmann, J. Proc. R. Soc. Lond. Ser. B 1957, 147, 258.
5. [5]
  Pestka, S. J. Biol. Chem. 2007, 282, 20047.
6. [6]
  Beck, H.; Härter, M.; Haß, B.; Schmeck, C.; Baerfacker, L. Drug Discov. Today 2022, 27, 1560.
7. [7]
  Clercq, E.; Li, G. Clin. Microbiol. Rev. 2016, 29, 695.
8. [8]
  Clercq, E. Nat. Rev. Microbiol. 2004, 2, 704.
9. [9]
  Ryu, W. S. Molecular Virology of Human Pathogenic Viruses; Elsevier: Amsterdam, the Netherlands, 2017; pp 31−45.
10. [10]
  Connolly, S.; Jackson, J.; Jardetzky, T.; Longnecker, R. Nat. Rev. Microbiol. 2011, 9, 369.
11. [11]
12. [12]
  Hitchings, G. H.; Elion, G. B.; Falco, E.; Russell, P. B.; Vanderwerff, H. Biol. Chem. 1950, 183, 1.
13. [13]
  Bieber, S.; Nigrelli, R. F.; Hitchings, G. H. Proc. Soc. Exp. Biol. Med. 1952, 79, 430.
14. [14]
15. [15]
  Prusoff, W. H. Biochim. Biophys. Acta 1959, 32, 295.
16. [16]
  Herrmann, E. C. Pro. Soc. Exp. Biol. Med. 1961, 107, 142.
17. [17]
  Kaufman, H. E.; Martola, E. L.; Dohlman, C. Arch. Ophthalmol. 1962, 68, 235.
18. [18]
  Wilhelmus, K. R. Cochrane Database Syst. Rev. 2010, 12, CD002898.
19. [19]
  Clercq, E. Clin. Microbiol. Rev. 1997, 10, 674.
20. [20]
  Clercq, E. Biochem. Pharmacol. 2004, 68, 2301.
21. [21]
  Andrei, G.; Sienaert, R.; McGuigan, C.; Clercq, E.; Balzarini, J.; Snoeck, R. Antimicrob. Agents Chemother. 2005, 49, 1081.
22. [22]
  Clercq, E.; Ashwell, M.; Jones, A. S.; Kumar, A.; Sayers, J. R.; Walker, R. T.; Sakuma, T. Tetrahedron 1987, 43, 4601.
23. [23]
  Asakura, J.; Robins, M. J. J. Org. Chem. 1990, 55, 4928.
24. [24]
  Glinski, R. P.; Khan, M. S.; Kalamas, R. L.; Sporn, M. B. J. Org. Chem. 1973, 38, 4299.
25. [25]
  Chu, C. K.; Beach, J. W.; Ullas, G. V.; Kosugi, Y. Tetrahedron Lett. 1988, 29, 5349.
26. [26]
  Fleet, G. W. J.; Son, J. C.; Derome, A. E. Tetrahedron 1988, 44, 625.
27. [27]
  Goodyear, M. D.; Hill, M. L.; West, J. P.; Whitehead, A. J. Tetrahedron Lett. 2005, 46, 8535.
28. [28]
29. [29]
  Jin, H. L.; Siddiqui, M. A.; Evans, C. A.; Tse, H. L. A.; Mansour, T. S.; Goodyear, M. D.; Ravenscroft, P.; Beels, C. D. J. Org. Chem. 1995, 60, 2621.
30. [30]
31. [31]
  Freed, E. O. Virology 1998, 251, 1.
32. [32]
  Kramer, R. A.; Schaber, M. D.; Skalka, A. M.; Ganguly, K.; Wong, S. F.; Reddy, E. P. Science 1986, 231, 1580.
33. [33]
  Roberts, N. A.; Martin, J. A.; Kinchington, D.; Broadhurst, A. V.; Craig, J. C.; Duncan, I. B.; Galpin, S. A.; Handa, B. K.; Kay, J.; Machin, P. J.; et al. Science 1990, 248, 358.
34. [34]
  Kaldor, S. W.; Kalish, V. J.; Davies, J. F.; Shetty, B. V.; Fritz, J. E.; Appelt, K.; Burgess, J. A.; Campanale, K. M.; Chirgadze, N. Y.; Clawson, D. K.; et al. J. Med. Chem. 1997, 40, 3979.
35. [35]
  Inaba, T.; Birchler, A. G.; Yamada, Y.; Sagawa, S.; Yokota, K.; Ando, K.; Uchida, I. J. Org. Chem. 1998, 63, 7582.
36. [36]
  Parkes, K. E. B.; Bushnell, D. J.; Crackett, P. H.; Dunsdon, S. J.; Freeman, A. C.; Gunn, M. P.; Hopkins, R. A.; Lambert, R. W.; Martin, J. A.; Merrett, J. H.; et al. J. Org. Chem. 1994, 59, 3656.
37. [37]
  Corey, E. J.; Zhang, F. Y. Angew. Chem. Int. Ed. 1999, 38, 1931.
38. [38]
  Kim, B. M.; Bae, S. J.; So, S. M.; Yoo, H. T.; Chang, S. K.; Lee, J. H.; Kang, J. S. Org. Lett. 2001, 3, 2349.
39. [39]
  Ghosh, A. K.; Kincaid, J. F.; Walters, D. E.; Chen, Y.; Chaudhuri, N. C.; Thompson, W. J.; Culberson, C.; Fitzgerald, P. M. D.; Lee, H. Y.; McKee, S. P.; et al. J. Med. Chem. 1996, 39, 3278.
40. [40]
  Yu, R. H.; Polniaszek, R. P.; Becker, M. W.; Cook, C. M.; Yu. L. H. L. Org. Process Res. Dev. 2007, 11, 972.
41. [41]
  Canoy, W. L.; Cooley, B. E.; Corona, J. A.; Lovelace, T. C.; Millar, A.; Weber, A. M.; Xie, S. P.; Zhang, Y. Org. Lett. 2008, 10, 1103.
42. [42]
  Ghosh, A. K.; Shin, D.; Packiarajan, M. Chem. Commun. 1999, 1025.
43. [43]
  Benedetti, F.; Norbedo, S. Chem. Commun. 2001, 203.
44. [44]
45. [45]
46. [46]
  Skehel, J. J.; Wiley, D. C. Annu. Rev. Biochem. 2000, 69, 531.
47. [47]
  Palese, P.; Jobita, K.; Ueda, M.; Compans, R. W. Virology 1974, 61, 397.
48. [48]
  Liu, C.; Eichelberger, M. C.; Compans, R. W.; Air, G. M. J. Virol. 1995, 69, 1099.
49. [49]
  Balakin, K. V.; Filosa, R.; Lavrenov, S. N.; Mkrtchyan, A. S.; Nawrozkij, M. B.; Novakov, I. A. Russ. Chem. Rev. 2018, 87, 509.
50. [50]
  Kadam, R. U.; Wilson, I. A. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 206.
51. [51]
  Air, G. M.; Laver, W. G.; Luo, M.; Stray, S. J.; Legrone, G.; Webster, R. G. Virology 1990, 177, 578.
52. [52]
  Blok, J.; Air, G. M.; Laver, W. G.; Ward, C. W.; Lilley, G. G.; Wood, E. F.; Roxburgh, C. M.; Inglis, A. S. Virology 1982, 119, 109.
53. [53]
  Colman, P. M. Pept. Protein Rev. 1984, 4, 215.
54. [54]
  Itzstein, M.; Wu, W. Y.; Kok, G. B.; Pegg, M. S.; Dyason, J. C.; Jin, B.; Phan, T. V.; Smythe, M. L.; White, H. F.; Oliver, S. W.; et al. Nature 1993, 363, 418.
55. [55]
  Chong, A. K. J.; Pegg, M. S.; Taylor, N. R.; von Itzstein, M. Eur. J. Biochem. 1992, 207, 335.
56. [56]
  Kim, C. U.; Lew, W.; Williams, M. A.; Liu, H. T.; Zhang, L. J.; Swaminathan, S.; Bischofberger, N.; Chen, M. S.; Mendel, D. B.; Tai, C. Y.; et al. J. Am. Chem. Soc. 1997, 119, 681.
57. [57]
  Rohloff, J. C.; Kent, K. M.; Postich, M. J.; Becker, M. W.; Chapman, H. H.; Kelly, D. E.; Lew, W.; Louie, M. S.; McGee, L. R.; Prisbe, E. J.; et al. J. Org. Chem.; 1998, 63, 4545.
58. [58]
  Federspiel, M.; Fischer, R.; Hennig, M.; Mair, H. J.; Oberhauser, T.; Rimmler, G.; Albiez, T.; Bruhin, J.; Estermann, H.; Gandert, C.; et al. Org. Process Res. Dev. 1999, 3, 266.
59. [59]
60. [60]
61. [61]
62. [62]
  Sagandira, C. R.; Mathe, F. M.; Guyo, U.; Watts, P. Tetrahedron 2020, 76, 131440.
63. [63]
  Hayashi, Y. J. Org. Chem. 2021, 86, 1.
64. [64]
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