Citation: Xilin Zhao, Xingyu Tu, Zongxuan Li, Rui Dong, Bo Jiang, Zhiwei Miao. Research Progress in Enantioselective Synthesis of Axial Chiral Compounds[J]. University Chemistry, ;2024, 39(11): 158-173. doi: 10.12461/PKU.DXHX202403106 shu

Research Progress in Enantioselective Synthesis of Axial Chiral Compounds

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China

Received Date: 29 March 2024
Revised Date: 13 June 2024

Axially chiral compounds possess unique chiral structures and have significant applications across diverse fields such as asymmetric catalysis, pharmaceuticals, optoelectronic materials, and natural products. In recent years, substantial advancements have been achieved in the enantioselective synthesis of these compounds. Beyond the conventional C—C and C—N axial chiral compounds, notable breakthroughs have been realized in the asymmetric synthesis of chiral compounds featuring N—N, C—S, C—O, and C—B axes. This review summarizes the recent progress in the asymmetric synthesis of various axially chiral compounds and discusses future directions in this research area.
- Axial chirality compounds,
- Enantioselective synthesis,
- Research progress
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