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Citation: LÜ Wenqiang, GENG Chao, XU Jingwei. Synthesis of Polyethylene Glycol Aldehyde Derivatives by Ozonation[J]. Chinese Journal of Applied Chemistry, ;2019, 36(1): 120-122. doi: 10.11944/j.issn.1000-0518.2019.01.180212 shu

Synthesis of Polyethylene Glycol Aldehyde Derivatives by Ozonation

LÜ Wenqiang ^a,b ,
GENG Chao ^a,, ,
XU Jingwei ^a,,

a.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China

Corresponding author: GENG Chao, cgeng@ciac.ac.cn XU Jingwei, jwxu@ciac.ac.cn
Received Date: 13 June 2018
Revised Date: 15 August 2018
Accepted Date: 12 September 2018

Fund Project: Supported by the National Natural Science Foundation of China(No.61504145)the National Natural Science Foundation of China 61504145

Figures(2)

Methoxypolyethylene glycol olefin was obtained by olefination of methoxypolyethylene glycol, and followed by ozonation to give methoxypolyethylene glycol aldehyde derivative. The properties of products were characterized by nuclear magnetic resonance spectroscopy(NMR) and matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS). The results show that the product has high purity and no by-products. The yields of methoxy polyethylene glycol acetaldehyde and polyethylene glycol propionaldehyde are as high as 98% and 99%, respectively, and the degrees of substitution are 90.87%~99.91% and 98%~100%, respectively.
- polyethylene glycol,
- ozonation,
- aldehyde
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