Citation: ZHANG Weijie, HUO Fangjun, YIN Caixia. A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite[J]. Chinese Journal of Applied Chemistry, ;2017, 34(12): 1457-1461. doi: 10.11944/j.issn.1000-0518.2017.12.170311 shu

A Coumarin Based Ratiometric Fluorescent Probe for Fast Sensing of Hypochlorite

a.
Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China
b.
Research Institute of Applied Chemistry, Shanxi University, Taiyuan 030006, China

Corresponding author: YIN Caixia, yincx@sxu.edu.cn
Received Date: 1 September 2017
Revised Date: 9 October 2017
Accepted Date: 11 October 2017

Fund Project: the National Natural Science Foundation of China 21775096the Shanxi Province Foundation for Returnee 2012-007the National Natural Science Foundation of China 201705105the National Natural Science Foundation of China 21672131Supported by the National Natural Science Foundation of China(No.21672131, No.21775096, No.201705105), the Talents Support Program of Shanxi Province(No.2014404), the Shanxi Province Foundation for Returnee(No.2012-007)the Talents Support Program of Shanxi Province 2014404

Figures(7)

Hypochlorous acid(HClO) is one of the biologically important reactive oxygen species(ROS), which plays important roles in the human immune defence system, and contributes to the destruction of invading bacteria and pathogens. Here, a novel ratiometric probe for detection of hypochlorite was designed and developed based on the coumarin. The sensor shows excellent selectivity, high sensitivity(12 nmol/L) and a rapid response(within 5 s) toward hypochlorite, accompanied with an obvious color change from colorless to yellow. Other anions and ROS all triggers very minor changes. Furthermore, the sensing mechanism was confirmed by electrospray ionization-mass spectrometry(ESI-MS) and spectrometry analysis, which was based on the strong oxidized by HClO/ClO^-, then hydrolyzed to generate fluorescent compound.
- coumarin,
- hypochlorite,
- fluorescence probe,
- fast response
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1.
沈阳化工大学材料科学与工程学院沈阳 110142