Citation: GUO Weifeng, XU Jinfang, LIU Ruiling, ZHAO Zhengbao, GUO Yuewei. Synthesis of Tetrandrine Derivatives and Their Biological Activity[J]. Chinese Journal of Applied Chemistry, ;2017, 34(7): 789-794. doi: 10.11944/j.issn.1000-0518.2017.07.160514 shu

Synthesis of Tetrandrine Derivatives and Their Biological Activity

a.
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China
b.
Chinese Academy of Sciences, Shanghai Institute of Materia Medica, Shanghai 201203, China

Corresponding author: ZHAO Zhengbao, zhengbao_z@163.com
Received Date: 21 December 2016
Revised Date: 21 February 2017
Accepted Date: 29 March 2017

Figures(1)

In order to explore more effective anti-tumor drugs, and improve the anti-tumor activities of tetrandrine, six new bisbenzylisoquinoline derivatives of tetrandrine were designed and synthesized by Suzuki coupling. The structures of these compounds were confirmed by ¹H nuclear magnetic resonance(¹H NMR), ¹³C nuclear magnetic resonance(¹³C NMR), and mass spectrometry(MS). Their inhibitory activities against human lung cancer cells(A549) and murine leukemia cells(P388) were evaluated by CCK-8(cell counting kit-8) method. All these compounds exhibit a certain level of anti-tumor activities, while compounds H1, H4, H6 possess better cytotoxicity profile than tetrandrine against A549 cells.
- tetrandrine,
- Suzuki coupling reaction,
- cell counting kit-8 method,
- anti-tumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142