Citation: ZHOU Feng, LIU Shu, LIU Zhiqiang, SONG Fengrui. Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis[J]. Chinese Journal of Applied Chemistry, ;2017, 34(6): 729-732. doi: 10.11944/j.issn.1000-0518.2017.06.160392 shu

Application of Methanol and Ethanol in Argon-Direct Real Time Mass Spectrometry Analysis

ZHOU Feng ^a,b ,
LIU Shu ^a ,
LIU Zhiqiang ^a ,
SONG Fengrui ^a,*,,

a.
National Center of Mass Spectrometry in Changchun, Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
University of the Chinese Academy of Sciences, Beijing 100039, China

Corresponding author: SONG Fengrui, songfr@ciac.ac.cn
Received Date: 28 September 2016
Revised Date: 15 December 2016
Accepted Date: 17 January 2017

Fund Project: the National Natural Science Foundation of China 81373952the National Natural Science Foundation of China 21673219

Figures(3)

In this research, argon was used as the running gas in direct analysis in real time mass spectrometry instead of helium in order to reduce the cost of experiment. Methanol and alcohol as reactive reagents improve the ionization efficiency of analytes and expand the application of Ar-DART-MS. This is because the above reagents play important roles as the medium of the energy transferring and the domor of proton in Ar-DART-MS analysis. Through the analysis of background signal from methol and alcohol as reactive reagents in Ar-DART-MS and their affect on sample ionization, the application scope of methanol and alcohol as reactive reagents in Ar-DART-MS was discussed. Some possible characteristic reactions were also explored. The validity of this method was verified by the analysis of reserpine.
- direct analysis in real time mass spectrometry,
- argon,
- methanol,
- alcohol
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