5-氟尿嘧啶修饰卟啉的合成及抗肿瘤活性

任丽磊 彭晓霞 赵秀丽 祝红梅

引用本文: 任丽磊, 彭晓霞, 赵秀丽, 祝红梅. 5-氟尿嘧啶修饰卟啉的合成及抗肿瘤活性[J]. 应用化学, 2016, 33(12): 1415-1419. doi: 10.11944/j.issn.1000-0518.2016.12.160054 shu
Citation:  REN Lilei, PENG Xiaoxia, ZHAO Xiuli, ZHU Hongmei. Synthesis and Antitumor Activity of Porphyrin Modified with 5-Fluorouracil[J]. Chinese Journal of Applied Chemistry, 2016, 33(12): 1415-1419. doi: 10.11944/j.issn.1000-0518.2016.12.160054 shu

5-氟尿嘧啶修饰卟啉的合成及抗肿瘤活性

    通讯作者: 任丽磊,讲师;Tel:0316-2188370;E-mail:renll1409@163.com;研究方向:有机合成
  • 基金项目:

    河北省教育厅青年基金(QN2014117) 

    廊坊师范学院青年基金(LSZQ201204)资助项目 

摘要: 合成了一种5-氟尿嘧啶修饰的自由卟啉(5-[2-(5-氟尿嘧啶-3-基)乙氧基苯基]-10,15,20-三(4-甲氧基苯基)卟啉)及其2种金属卟啉配合物:5-[2-(5-氟尿嘧啶-3-基)乙氧基苯基]-10,15,20-三(4-甲氧基苯基)锰卟啉和5-[2-(5-氟尿嘧啶-3-基)乙氧基苯基]-10,15,20-三(4-甲氧基苯基)锌卟啉。通过紫外可见光谱(UV-Vis)、红外光谱(IR)和核磁共振谱氢谱(1H NMR)对目标化合物进行了结构表征。用噻唑蓝法(MTT法)测定了自由卟啉、锰卟啉及锌卟啉分别对肺腺癌细胞株A549、肝癌细胞株Bel7402和人结肠癌细胞株HCT-8的抑制活性。其中,锰卟啉对人结肠癌细胞株HCT-8的半抑制浓度为IC50为17.8 mg/L,具有一定的细胞毒作用。

English

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  • 收稿日期:  2016-02-01
  • 网络出版日期:  2016-04-12
通讯作者: 陈斌, bchen63@163.com
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