Citation: WEN Lijun, WANG Ying, LI Haixia, LI Juan. Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu[J]. Chinese Journal of Applied Chemistry, ;2016, 33(9): 1056-1060. doi: 10.11944/j.issn.1000-0518.2016.09.150302 shu

Synthesis and Antibacterial Activity of 5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu

WEN Lijun ^a ,
WANG Ying ^b ,
LI Haixia ^a,, ,
LI Juan ^a

1.
a College of Pharmacy, Hainan Medical College, Haikou 571199, China;
2.
b Tropical and Laboratory Medicine School, Hainan Medical College, Haikou 571199, China

Corresponding author: LI Haixia,
Received Date: 19 August 2015
Available Online: 5 January 2016
Fund Project:

5,6-Dimethyl-2,3-pyrazinedimethylformamide-Cu was prepared from Cu(CH₃COO)₂ and 5,6-dimethyl-2,3-pyrazinedimethylformamide which was synthesized via hydrolysis of 5,6-dimethyl-2,3-pyrazinecarbonitrile in the dilute basic solution using H₂O₂ as the oxidant. The antibacterial activity of 5,6-dimethyl-2,3- pyrazinedimethylformamide and the complex were compared by the Oxford cup method and tube double dilution method. The complex was characterized by UV and IR spectroscopies and TGA. The 5,6-dimethyl-2,3-pyrazinedimethylformamide-Cu shows good bacteriostatic and bactericidal effects. Both the minimum antimicrobial and the germicidal dosages against E.coli and Staphylococcus aureus are 50 mg/L and 25 mg/L, respectively, while 5,6-dimethyl-2,3-pyrazinedimethylformamide does not show obvious inhibitory effect, providing a reference for the clinical treatment of diseases and the development of food additives.
- dimethyl-pyrazinedimethylformamide,
- copper complex,
- synthesis,
- antibacterial activity
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