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Citation: WANG Haoran, YANG Weicheng, TU Yahui, YANG Chao, FANG Chao, LI Meihua, LUO Yong, WU Fanhong. Synthesis and Properties of Stable Isotope Deuterium Labeled D4-Rhodamine B[J]. Chinese Journal of Applied Chemistry, ;2016, 33(8): 939-944. doi: 10.11944/j.issn.1000-0518.2016.08.150374 shu

Synthesis and Properties of Stable Isotope Deuterium Labeled D4-Rhodamine B

  • 1.

    a School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China;

  • 2.

    b Shanghai Research Institute of Chemical Industry, Shanghai 200062, China;

  • 3.

    c National Isotope Engineering Technology Research Center-Shanghai Sub-Center, Shanghai 200062, China

  • Corresponding author: LUO Yong, 
  • Received Date: 21 October 2015
    Available Online: 25 April 2016

    Fund Project:

  • This paper presents an efficient synthesis of stable isotope labeled D4-rhodamine B from deuterated orthoxylene through oxidation and its reaction with 3-diethylaminophenol in 36.9% total yield. The deuterated product was confirmed by mass spectrometry(MS) and nuclear magnetic resonance(NMR). Its chemical purity is higher than 98.0% by high performance liquid chromatography(HPLC), and isotopic enrichment is higher than 98.0%(atom D). D4-rhodamine B was used as internal standard for the determination of rhodamine B in orange juice with linear calibration curve of 0.05~50 mg/L, limit for determination of 5 μg/kg, recovery of 96.4%~103.4% and relative standard deviation(RSD) of 1.0%~1.2%. This method is proved to be accurate and sensitive for the determination of rhodamine in food safety.
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