Citation: ZHANG Chenglu, CHENG Anqi, TANG Jie, GUO Yang, SUN Lijie, XI Huan. Synthesis and Biological Activity of the Novel Mannich Bases of 5-Alkyl-1,2,4-triazole[J]. Chinese Journal of Applied Chemistry, ;2016, 33(5): 554-564. doi: 10.11944/j.issn.1000-0518.2016.05.150267 shu

Synthesis and Biological Activity of the Novel Mannich Bases of 5-Alkyl-1,2,4-triazole

1.
College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, Liaoning 116029, China

Corresponding author: ZHANG Chenglu,
Received Date: 28 July 2015
Available Online: 7 December 2015
Fund Project:

Twenty-two novel Mannich bases of 5-alkyl-1,2,4-triazole were designed and synthesized to evaluate their biological activities. The plant growth regulating activity, herbicidal activity and the inhibitory activity on cell division cycle protein 25B(CDC25B) of those molecules were screened. Most of the molecules exhibit good cytokinin activity and herbicidal activity, indicating their potential as novel pesticide. One of these molecules performs good inhibitory activity against CDC25B, and is a potential leading compound for anti-concer drug design.
- alkyl-triazole,
- Mannich base,
- plant growth regulator,
- herbicidal activity,
- inhibitors against CDC25B
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沈阳化工大学材料科学与工程学院沈阳 110142