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Citation: XU Zhaohui, LIU Deyong, TU Yuanhong. Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst[J]. Chinese Journal of Applied Chemistry, ;2015, 32(9): 999-1004. doi: 10.11944/j.issn.1000-0518.2015.09.150038 shu

Efficient Solvent-free Synthesis of Spiro Heterobicyclic Derivatives with Boric Acid as Catalyst

1.
National Monosaccharide Chemical Synthesis Engineering Research Center, Jiangxi Normal University, Nanchang 330027, China

Corresponding author: XU Zhaohui,
Received Date: 2 February 2015
Available Online: 26 March 2015
Fund Project: 国家科技攻关计划(2001BA323C) (2001BA323C)江西省研究生创新基金(YC2015-B030)资助项目 (YC2015-B030)

Eight spiro heterobicyclic compounds were synthesized by the three component condensation reaction of aromatic aldehydes with urea and 2,2-dimethyl-1,3-dioxane-4,6-dione using boric acid as catalyst under solvent-free conditions.The results indicate that the yields range from 84% to 94% at 80℃ for 2.0~4.0 h using 10% molar fraction of boric acid (relative to the substrate of 2,2-dimethyl-1,3-dioxane-4,6-dione).Furthermore,a mechanism for the reaction catalyzed by boric acid was proposed.The main advantages of the present procedure are mild conditions,short reaction time and high yields.
- boric acid,
- solvent-free,
- three component condensation reaction,
- spiro heterobicyclic derivatives
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