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Citation: WANG Kunteng, WANG Laiyou, LAN Wenjian, YAN Danfeng, LI Houjin. Hydroxylated Biotransformation of Flavone by Marine Fungi Induced Degradation of Benzene and Toluene[J]. Chinese Journal of Applied Chemistry, ;2015, 32(6): 671-675. doi: 10.11944/j.issn.1000-0518.2015.06.140346 shu

Hydroxylated Biotransformation of Flavone by Marine Fungi Induced Degradation of Benzene and Toluene

1.
a Institute of Chinese Medical Sciences, Guangdong Pharmaceutical University, Guangzhou 510006, China;
2.
b School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China;
3.
c School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China

Corresponding author: LI Houjin,
Received Date: 13 October 2014
Available Online: 28 January 2015
Fund Project: 广东省科技计划项目(2012A031100005,2013B021100010,2013B021100012) (2012A031100005,2013B021100010,2013B021100012)广东省自然科学基金项目(S2012010010653)资助 (S2012010010653)

Aromatic hydrocarbons can be degraded by fungi. However,the application of the highly active oxidases induced in the degradation process is still rare. This paper investigated the biotransformation of flavone by marine fungi Pseudallescheria boydii and Trichoderma erinaceum cultured in the media containing benzene and toluene. Pseudallescheria boydii and Trichoderma erinaceum show strong tolerance to benzene and toluene. The hydroxylation enzymes activated by the degradation processes of benzene and toluene are responsible for the biotransformation of flavones,which gives the only product 4'-hydroxy flavones with high regioselectivity. Furthermore,the transformation yield can reach up to 82%. This biotransformation induced by the degradation of benzene and toluene may have potential applications in the field of enzyme-catalyzed reactions.
- marine fungi,
- benzene,
- toluene,
- flavone,
- biotransformation,
- hydroxylation
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