Abstract: Polymeric nanocarriers with controllable drug realease and stimuli-responsive to targeted biological conditions are an advancing and potential carrier candidate for nanomedicines. Hyperbranched polyglycerols(HPG) spur the interest of the biomaterial community due to their well-defined three-dimensional structures,good solubility,high biocompatiblity and multiple attachment sites for modification. Functionally modified HPG derivatives are able to self-assemble into a variety of drug carriers such as micelles and vesicles. Herein,we present the current progress on functional modified HPG for drug delivery with particular focus on amphiphilic modification, stimuli-responsive functionalization, as well as supra molecular self-assembly.Molecular design strategy for HPG modification with amphiphilic and stimuli responsive functionalization is systematically summarized. Furthermore,the assembly behavior of hyperbranched supra molecular polyglycerol copolymers based on cyclodextrin host-guest interactions is also mentioned.