Citation: DONG Jian-Wei, XIA Ling, LI Gong-Ke. Progress in Enrichment Techniques of Circulating Tumor Cells[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(12): 1851-1862. doi: 10.11895/j.issn.0253-3820.181515 shu

Progress in Enrichment Techniques of Circulating Tumor Cells

School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China

Received Date: 6 August 2018
Revised Date: 10 September 2018

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21675178, 21475153), the Natural Science Foundation of Guangdong Province, China (No. 2018A030313241), the Special Funds for Public Welfare Research and Capacity Building in Guangdong Province of China (No. 2015A030401036), and the Guangzhou Minsheng Science and Technology Major Project of China (No.201604020165)

Circulating tumor cells (CTCs) are rare tumor cells shed from primary and metastatic tumor sites into the circulation and have great clinical significance for the early diagnosis and prognosis of cancer patients, as well as have potential value in personalized cancer therapy and drug development. However, CTCs are often rare in blood sample. Therefore, the development of enrichment techniques is turning out to be the bottleneck of its clinical application. Additionally, the distribution of CTCs subtypes and the molecular identification and functional analysis of viable CTCs are more helpful for clinical diagnosis and personalized cancer therapy, and higher requirements for CTCs enrichment technique are put forward. In this paper, the progress in enrichment of CTCs and its subtype capture and post-capture nondestructive release in recent years were reviewed, and the future trends of CTCs enrichment technologies including the challenge and opportunity were discussed.
- Circulating tumor cells,
- Enrichment,
- Sub-phenotypes,
- Release,
- Review
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