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Citation: ZHU Teng-Gao, HAN Jing, SHU Jun-Wen, KE Mu-Fang, WANG Dan, LIU Wen-Jie, LIN Nian-Xiang, CHEN Huan-Wen. In vivo Breath Analysis by Extractive Electrospray Ionization-Mass Spectrometry for Investigation of Metabolic Responses to Traditional Chinese Medicine Massages[J]. Chinese Journal of Analytical Chemistry, ;2018, 46(3): 400-405. doi: 10.11895/j.issn.0253-3820.171359 shu

In vivo Breath Analysis by Extractive Electrospray Ionization-Mass Spectrometry for Investigation of Metabolic Responses to Traditional Chinese Medicine Massages

1.
East China University of Technology, Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, Nanchang 330013, China;
2.
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China;
3.
De Yi Tian He Health Care Centre, Beijing 100089, China

Received Date: 20 October 2017
Revised Date: 28 November 2017

Fund Project: This work was supported by the 111 Project (No. D17006), the National Natural Science Foundation of China (No. 21520102007), and the Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation Open Fund (No. JXMS201518).

Traditional Chinese Medicine massage is a kind of physiotherapy which affects on specific parts of the body surface by means of training to regulate the function of the body to achieve the therapeutic effect. In this work, under positive detection model, the chemical fingerprint of exhaled breath from volunteers before and after receiving Traditional Chinese Medicine massage within m/z 50-1000 were detected by extractive electrospray ionization-mass spectrometry (EESI-MS). And through high resolution mass spectrometry analysis, the metabolites such as epinephrine (m/z 184.0889), 3-(3-hydroxyphenyl) propionic acid (m/z 167.0615) and L-tryptophan (m/z 205.0933) were successfully identified. Besides, chemical fingerprints of volunteers before and after receiving Traditional Chinese Medicine massage under different health condition were clearly differentiated via partial least squares discrimination analysis (PLS-DA). The results showed that Traditional Chinese Medicine massage could significantly change the metabolic process of volunteers. Moreover, it further indicated that the established method could provide a real time fashion to follow metabolic changes caused by Traditional Chinese Medicine massage.
- Exhaled breath,
- Mass spectrometry,
- Partial least squares discrimination analysis,
- Traditional Chinese Medicine massage
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