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Citation: MA Zhen-Zhen, YU Hui-Cheng, WU Zhao-Yang, WU Yan, XIAO Fu-Bing. A Highly Sensitive Amperometric Glucose Biosensor Based on Nano-cube Cu₂O Modified Glassy Carbon Electrode[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(5): 822-827. doi: 10.11895/j.issn.0253-3820.150617 shu

A Highly Sensitive Amperometric Glucose Biosensor Based on Nano-cube Cu₂O Modified Glassy Carbon Electrode

1.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China;
2.
School of Chemistry and Chemical Engineering, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Key Laboratory of Guangxi Colleges and Universities for Food Safety and Pharmaceutical Analytical Chemistry, Guangxi University for Nationalities, Nanning 530008, China

Received Date: 4 August 2015
Revised Date: 18 January 2016

Fund Project: This work was supported by the National Natural Science Foundation of China (Nos. 21175037, 21277042) and the Guangxi Natural Science Foundation (No. 2015GXNSFAA139040)

A highly sensitive amperometric glucose biosensor was fabricated by using the synthesized nano-cube copper (Ⅰ) oxide (Cu₂O). The synthesized nano-Cu₂O and the modified electrode were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM). The results showed that the obtained samples were nano-cube Cu₂O. The electrochemical properties of the modified electrode were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), and chronoamperometry (CA). The CV behavior of nano-cube Cu₂O modified sensor was examined in 0.1 mol/L PBS (pH 7.4) containing 0.1 mmol/L glucose. The experimental results showed the prepared sensor presented remarkably enhanced electrocatalytic activity towards glucose detection. Linear responses of the sensor to glucose were observed for gulcose concentrations ranging from 5.0×10^-6 mol/L to 4.0×10^-3 mol/L (r²=0.9983), with a detection limit of 6.8×10^-7 mol/L (S/N=3). The CA results showed that the interference from potential interfering species such as uric acid, ascorbic acid, and D fructose could be ignored. In addition, the developed sensor exhibited good repeatability and stability, and was successfully applied to the determination of glucose in real urea samples from diabetics.
- Nano-cube copper (Ⅰ) oxide,
- Glucose oxidase,
- Glucose,
- Electrocatalysis,
- Biosensor
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A Highly Sensitive Amperometric Glucose Biosensor Based on Nano-cube Cu₂O Modified Glassy Carbon Electrode