Citation: CHEN Wei, CHEN Yu-Quan. Fabrication of Flexible Continuous Glucose Monitoring Sensor by Non-Patterning Method[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(4): 654-659. doi: 10.11895/j.issn.0253-3820.150542 shu

Fabrication of Flexible Continuous Glucose Monitoring Sensor by Non-Patterning Method

CHEN Wei ,
CHEN Yu-Quan ^,

1.
College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310027, China

Corresponding author: CHEN Yu-Quan,
Received Date: 7 July 2015
Available Online: 29 February 2016

A tight gold layer was electroless plated on polyimide film coated with polydopamine. A polyurethane coated flexible glucose sensor was developed based on this two side gold layer structure, wherein the platinum black plating side was used as reference-counter electrode and another side that was successively modified by platinum black layer, Nafion/carbon nanotube(CNT) layer and glucose oxidase(Gox) layer as working electrode. The morphology of each layer and its influence on glucose sensing performance were investigated. The glucose biosensor showed a linear range from 2.0 to 32.0 mmol/L and the sensitivity was 25μA·(mmol/L)^-1·cm^-2 at low potential of 0.3 V, with a detection limit of 0.05 mmol/L(S/N=3). The biosensor could avoid the commonly coexisted interference and exhibited high stability in the continuous subcutaneous glucose monitoring.
- Surface metallization,
- Flexible sensor,
- Continuous glucose monitoring,
1. [1]
  1 Mastrototaro J. J. Pediatr. Endocr Met., 1999, 123:751-758
2. [2]
  2 Hoss U, Jeddi I, Schulz M, Budiman E, Bhogal C, McGarraugh G. Diabetes Technol., 2010, 12(8):591-597
3. [3]
  3 Heller A, Feldman B. Accounts Chem. Res., 2010, 43(7):963-973
4. [4]
  4 Koschwanez H E, Yap F Y, Klitzman B, Reichert W M. J. Biomed. Mater. Res. A, 2008, 87A(3):792-807
5. [5]
  5 Shults M C, Rhodes R K, Updike S J. Brauker J H. U.S. Patent, US07901354, 2011
6. [6]
  6 Wilson G S, Zhang Y, Reach G, Moattisirat D, Poitout V, Thevenot D R, Lemonnier F, Klein J C. Clin. Chem., 1992, 38(9):1613-1617
7. [7]
  7 Lu Z, Xiao J, Wang Y, Meng M. J. Colloid Interf. Sci., 2015, 452:8-14
8. [8]
  8 Horiuchi S, Nakao Y. Surf. Coat. Tech., 2010, 204(23):3811-3817
9. [9]
  9 Ball V, Del Frari D, Toniazzo V, Ruch D. J. Colloid Interf. Sci., 2012, 386:366-372
10. [10]
  10 Heli H, Sattarahmady N, Vais R D, Mehdizadeh A R. Sens. Actuator B, 2014, 192:310-316
11. [11]
  11 Jung-Chuan C, Jhang C, Yi-Hung L, Lin J, Chen R, Hsueh-Tao C. IEEE T. Semiconduct. M., 2014, 27(4):523-529
12. [12]
  12 Guo M Q, Hong H S, Tang X N, Fang H D, Xu X H. Electrochim. Acta, 2012, 63:1-8
13. [13]
  13 Park S, Boo H, Chung T D. Anal. Chim. Acta, 2006, 556(1):46-57
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