Citation: LI Xin-Xin, CHEN Lin-Fei, OUYANG Yong-Zhong, FENG Fang, CHEN Huan-Wen. Method for Improving Spatial Resolution of Liquid-assisted Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2016, 44(1): 25-31. doi: 10.11895/j.issn.0253-3820.150188 shu

Method for Improving Spatial Resolution of Liquid-assisted Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry

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¹ Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China;
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² Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, East China Institute of Technology, Nanchang 330013, China

Corresponding author: FENG Fang,
Received Date: 18 March 2015
Available Online: 17 July 2015
Fund Project: 本文系国家自然科学基金资助项目(Nos.21225522,21265001) (Nos.21225522,21265001)教育部新世纪优秀人才支持计划资助项目(No.NCFT-11-0999) (No.NCFT-11-0999)

Liquid-assisted surface desorption atmospheric pressure chemical ionization source (LA-DAPCI) technique shows good potential in complex matrix mass spectrometry imaging. Due to primary ions and high density charged droplets of solvent generated by corona discharge, analytes on sample surface are extracted and ionized efficiently. However, direct application of the DAPCI ionization for mass spectrometry imaging of complex matrix analytes usually tends to be challenging because of low spatial resolution. To resolve this problem, several ion source parameters and experiment conditions were optimized in the present work, including ion source configuration, chemical composition of the extraction solvent, geometry parameters, solvent flow rate and pressure of nebulizing gas. The results presented here confirmed that the spatial resolution of LA-DAPCI was improved (from (441±14) μm to (58±7) μm). The proposed LA-DAPCI-MS/MS method was then successfully used to profile the distribution of Rhodamine 6G with a limit of detection of 0.01 ng/cm².
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