Citation: Hanxue LIU, Shijie LI, Meng REN, Xuling XUE, Hongke LIU. Design and antitumor properties of dehydroabietic acid functionalized cyclometalated iridium(Ⅲ) complex[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(8): 1483-1494. doi: 10.11862/CJIC.20250031 shu

Design and antitumor properties of dehydroabietic acid functionalized cyclometalated iridium(Ⅲ) complex

Hanxue LIU ¹ ,
Shijie LI ¹ ,
Meng REN ¹ ,
Xuling XUE ^{1, 2,,} ,
Hongke LIU ^{1, 2,,}

1.
School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
2.
State Key Laboratory of Coordination Chemistry, Nanjing 210023, China

Corresponding author: Xuling XUE, xuexuling87@163.com Hongke LIU, liuhongke@njnu.edu.cn
Received Date: 25 January 2025
Revised Date: 16 June 2025

Figures(8)

A novel cyclometalated iridium complex, CycIr-DHA, was successfully synthesized by incorporating the natural product dehydroabietic acid (DHA) into the cyclometalated iridium framework, and the ligand and complex were characterized by ¹H NMR. The complex showed strong antitumor effects on various cancer cells, especially michigan cancer foundation-7 (MCF-7) cells, with a half maximal inhibitory concentration (IC₅₀) of 2.5 μmol·L^-1, superior to that of the traditional chemotherapeutic drug cisplatin. Experimental results indicated that CycIr-DHA primarily accumulated in the mitochondria of MCF-7, leading to a significant increase in intracellular reactive oxy- gen species levels and subsequent mitochondrial dysfunction. Furthermore, the complex modulated the expression of apoptosis - related proteins (Bax and Bcl - 2), promoting apoptosis, and upregulates LC3 - Ⅱ protein, inducing autophagy. In a 3D cell spheroid model, CycIr-DHA significantly inhibited the growth of the spheroids.
- dehydroabietic acid,
- cyclometalated iridium complex,
- apoptosis,
- autophagy,
- antitumor
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