Citation: Lifang HE, Wenjie TANG, Yaoze LUO, Mingsheng LIANG, Jianxin TANG, Yuxuan WU, Fuxing ZHANG, Xiaoming ZHU. Synthesis, structure, and anticancer activity of two dialkyltin complexes constructed based on 2, 2′-bipyridin-6, 6′-dicarboxylic acid[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(8): 1601-1609. doi: 10.11862/CJIC.20250012 shu

Synthesis, structure, and anticancer activity of two dialkyltin complexes constructed based on 2, 2′-bipyridin-6, 6′-dicarboxylic acid

Lifang HE ^{1, 2} ,
Wenjie TANG ³ ,
Yaoze LUO ³ ,
Mingsheng LIANG ³ ,
Jianxin TANG ³ ,
Yuxuan WU ³ ,
Fuxing ZHANG ^{2, 3, 4,,} ,
Xiaoming ZHU ^{2, 3, 4}

1.
Department of Life Sciences, Hengyang Normal University, Hengyang, Hunan 421008, China
2.
Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Hengyang Normal University, Hengyang, Hunan 421008, China
3.
Department of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China
4.
Key Laboratory of Organometallic New Materials, University of Hunan Province, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: Fuxing ZHANG, zfx8056@163.com
Received Date: 9 January 2025
Revised Date: 1 June 2025

Figures(6)

Di(o-fluorobenzyl)tin-2, 2′-bipyridine-6, 6′-dicarboxylic acid complex [Sn(o-F-C₆H₄CH₂)₂(bpdc)(H₂O)]₂·H₂O (1) and di-n-butyltin-2, 2′-bipyridine-6, 6′-dicarboxylic acid complex [Sn(n-C₄H₉)₂(bpdc)(H₂O)]·H₂O (2) were synthesized via a solvothermal method using anhydrous ethanol as the solvent. The complexes were characterized by elemental analysis, IR spectroscopy, NMR(¹H, ¹³C, and ¹¹⁹Sn), and thermogravimetric analysis. The crystal structures of the complexes were determined by the single-crystal X-ray diffraction method. The complexes are all single tin core molecules, belonging to the orthorhombic(Pbca) and monoclinic(P2₁/c) crystal systems, respectively. The central tin atoms are in a pentagonal bipyramidal configuration with seven coordination. The in vitro antitumor activities of the complexes against human gastric adenocarcinoma (AGS), acute lymphoblastic leukemia (MOLT4), and breast cancer (MDA-MB-231) cell lines were evaluated using the CCK-8 assay. Complex 1 demonstrated potent inhibitory effects across all tested cell lines, while complex 2 showed strong activity against AGS and MOLT4 but significantly reduced efficacy toward MDA-MB-231.
- dialkyltin complex,
- synthesis,
- crystal structure,
- in vitro antitumor activity
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