Citation: Bin SUN, Heyan JIANG. Glucose-modified bis-Schiff bases: Synthesis and bio-activities in Alzheimer′s disease therapy[J]. Chinese Journal of Inorganic Chemistry, ;2025, 41(7): 1338-1350. doi: 10.11862/CJIC.20240428 shu

Glucose-modified bis-Schiff bases: Synthesis and bio-activities in Alzheimer′s disease therapy

Bin SUN ^1,, ,
Heyan JIANG ²

1.
School of Food Science and Engineering, Chongqing Technology and Business University, Chongqing 400067, China
2.
School of Environment and Resources, Chongqing Technology and Business University, Chongqing 400067, China

Corresponding author: Bin SUN, sunbin@ctbu.edu.cn
Received Date: 4 December 2024
Revised Date: 1 June 2025

Figures(8)

The dyshomeostasis of metal ions is one of the pathogeneses of Alzheimer′s disease (AD), and metal chelation therapy is a promising approach for the treatment of AD. In this work, three glucose-modified bis-Schiff bases were designed and synthesized. Their biological activities in treating AD in vitro were measured by turbidity assay, HRP/Amplex Red assay, fluorescent probe of DCFH-DA, NBT analysis, and MTT assay. The results were compared with cliquinol (CQ) and non-glucose-modified analogues. It was found that the glucose modified bis-Schiff bases had more efficient bio-activities in inhibiting metal ions (Cu²⁺, Zn²⁺) induced Aβ_1-40 aggregation, decreasing the level of reactive oxygen species (ROS) in Cu²⁺-Aβ treated PC 12 cells, increasing the activity of superoxide dismutase in Cu²⁺-Aβ treated PC 12 cells and attenuating the cytotoxicity mediated by metal ions induced Aβ aggregation than CQ. The toxicity of glucose-modified bis-Schiff bases was lower than that of non-glucose functionalized analogues. The bio-activities of glucose-modified bis-Schiff bases on anti-oxidative and improving the survival rate of PC12 cells treated with Aβ and metal ions, were superior to those of non-glucose-modified analogues.
- synthesis,
- glucose,
- Alzheimer′s disease,
- bis-Schiff base,
- anti-oxidant
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