Citation: Peng GENG, Guangcan XIANG, Wen ZHANG, Haichuang LAN, Shuzhang XIAO. Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(10): 1903-1910. doi: 10.11862/CJIC.20240155 shu

Hollow copper sulfide loaded protoporphyrin for photothermal-sonodynamic therapy of cancer cells

Peng GENG ^{1, 2} ,
Guangcan XIANG ³ ,
Wen ZHANG ³ ,
Haichuang LAN ^{2, 3} ,
Shuzhang XIAO ^{2, 3,,}

1.
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei 443002, China
2.
Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials, College of Materials and Chemical Engineering, China Three Gorges University, Yichang, Hubei 443002, China
3.
Hubei Three Gorges Laboratory, Yichang, Hubei 443007, China

Corresponding author: Shuzhang XIAO, shuzhangxiao@ctgu.edu.cn
Received Date: 5 May 2024
Revised Date: 14 July 2024

Figures(5)

Hollow copper sulfide (H-Cu_2-xS) nanoparticles were developed and multifunctional nanoagent (PpIX@H-Cu_2-xS) was obtained by loading sonosensitizers protoporphyrin (PpIX) in their cavity structures. H-Cu_2-xS had a good photothermal conversion effect under near-infrared (NIR) light irradiation conditions and had a large specific surface area (68 m²·g^-1), which could realize efficient loading of sonosensitizers PpIX. Under ultrasonic (US) excitation conditions (10 min), it was found that 46.1% of 1, 3-diphenylisobenzofuran (DPBF) was oxidized by reactive oxygen species (ROS) produced by PpIX@H-Cu_2-xS. In vitro cell experiments, PpIX@H-Cu_2-xS had shown good biosafety and could effectively kill tumor cells under NIR/US excitation conditions.
- hollow copper sulfide,
- protoporphyrin,
- photothermal therapy,
- sonodynamic therapy,
- reactive oxygen species
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