Citation: Chao LIU, Jiang WU, Zhaolei JIN. Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(10): 1986-1994. doi: 10.11862/CJIC.20240153 shu

Synthesis, crystal structures, and antibacterial activities of two zinc(Ⅱ) complexes bearing 5-phenyl-1H-pyrazole group

Chao LIU ^{1, 2,,} ,
Jiang WU ¹ ,
Zhaolei JIN ¹

1.
School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, Anhui 234000, China
2.
Anhui Key Laboratory of Spin Electron and Nanomaterials, Suzhou, Anhui 234000, China

Corresponding author: Chao LIU, kykrliu@163.com
Received Date: 4 May 2024
Revised Date: 28 August 2024

Figures(7)

A novel compound (H₂L)SCN (5-methyl-3-phenyl-2H-pyrazol-1-ium thiocyanate) has been obtained by the reaction of thiosemicarbazide with benzoylacetone in ethanol. Two zinc(Ⅱ) complexes [Zn(HL)₂(NCS)(CH₃COO)] (1) and [Zn₂(L)₂(HL)₂(NCS)₂]₂·2CH₃OH (2) have been synthesized by the coordination reactions of Zn(OAc)₂·2H₂O or ZnCl₂ with (H₂L)SCN under reflux conditions. Elemental analyses and single-crystal X-ray diffraction have confirmed the structures of the synthesized compounds. The (H₂L)SCN ligand and complex 1 pertain to the triclinic system with space group P1, while complex 2 belongs to the monoclinic system with space group P2₁/n. Additionally, the antibacterial activities of the compounds were evaluated in vitro using the agar diffusion method against the bacterial strains (Candida albicans, Staphylococcus aureus, and Escherichia coli). The results showed that the ligand exhibited relatively good antibacterial activities against the bacteria, and the complexes possessed stronger antibacterial activities against the same bacteria than the free ligand.
- zinc(Ⅱ) complex,
- 5-phenyl-1H-pyrazole,
- thiocyanate,
- crystal structure,
- bacteria
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