Citation: Ge ZHANG, Wenjiang YANG, Yu LIU. Advances in positron emission tomography imaging tracers for the central dopamine system[J]. Chinese Journal of Inorganic Chemistry, ;2024, 40(1): 54-70. doi: 10.11862/CJIC.20230387 shu

Advances in positron emission tomography imaging tracers for the central dopamine system

Ge ZHANG ^{1, 2} ,
Wenjiang YANG ^{1, 3,,} ,
Yu LIU ^{1, 2, 3,,}

1.
Institute of High Energy Physics, Chinese Academy of Sciences, Beijing Engineering Research Center of Radiographic Techniques and Equipment, Beijing 100049, China
2.
University of Chinese Academy of Sciences, Beijing 100049, China
3.
Jinan Laboratory of Applied Nuclear Science, Jinan 250131, China

Corresponding author: Wenjiang YANG, yangwj@ihep.ac.cn Yu LIU, yuliu@ihep.ac.cn
Received Date: 16 October 2023
Revised Date: 15 December 2023

Figures(11)

The central dopamine system plays a crucial role in the pathophysiology of various neurobehavioral disorders. Positron emission tomography (PET) imaging has been instrumental in studying dopamine biochemical processes in the living brain. PET imaging utilizes positron-emitting radionuclide ¹¹C/¹⁸F-labelled tracers to assess dopamine synthesis, vesicle storage, synaptic release, receptor binding, and reuptake processes by binding to specific targets in the dopamine nervous system. This advancement has significantly contributed to research in neurology, psychiatry, drug abuse and addiction, and therapeutic drug development. This article provides a comprehensive review of the progress in ¹¹C/¹⁸F-labelled PET imaging agents targeting amino acid decarboxylase, dopamine transporters, dopamine receptors, and vesicular monoamine transporters.
- positron emission tomography,
- radiotracer,
- dopamine system,
- dopamine receptor,
- transporter
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