Citation: Jing-Xiang ZHANG, Wai-Kwok WONG, Ka-Leung WONG, Nai-Ki MAK. Highly Conjugated Tetraphenylporphyrin-Ru(Ⅱ) Bipyridine Complex: Synthesis, Optical Properties, and Photodynamic Anticancer Activity[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(12): 2383-2391. doi: 10.11862/CJIC.2022.240 shu

Highly Conjugated Tetraphenylporphyrin-Ru(Ⅱ) Bipyridine Complex: Synthesis, Optical Properties, and Photodynamic Anticancer Activity

1.
School of Chemistry and Environmental Engineering, Hanshan Normal University, Chaozhou, Guangdong 521041, China
2.
Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Hong Kong 999077, China
3.
Department of Biology, Faculty of Science, Hong Kong Baptist University, Hong Kong 999077, China

Corresponding author: Jing-Xiang ZHANG, zhangjx@hstc.edu.cn
Received Date: 10 May 2022
Revised Date: 4 September 2022

Figures(6)

Two amphiphilic porphyrin-ruthenium (Ⅱ) complexes PorRu and PorZn-Ru were synthesized by the coordination of metal Ru(Ⅱ) and porphyrin-phenanthroline ligand L which is modified with conjugated pyrazine ring at the β position of porphyrin. Two compounds were characterized and evaluated by NMR and mass spectrometry, linear and nonlinear spectral analysis, and photodynamic anti-cancer activity study. Experimental results show that the two compounds had very high ¹O₂ quantum yields (0.93, 0.82), high two-photon absorption cross-sections (619, 621 GM), and up to about 22 nmol per 10⁶ cell uptakes of nasopharyngeal carcinoma HK-1 cell line. Although no obvious subcellular target was observed by the costaining cell images, the high ¹O₂ yields and good cellular uptakes still made the ruthenium compounds have good photodynamic anticancer activity against HK-1 cells. At the light dose of 2 J·cm^-2 and the administration concentration of 4 μmol·L^-1, the inhibition efficiency reached (87.44±2.21)% and (45.03±2.85)% respectively.
- porphyrin,
- ruthenium complex,
- amphiphilicity,
- two-photon,
- photodynamic therapy
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