Citation: Xiao-Hong LI, Xian-Wei WU, Yuan WANG, Wei-Na WU. Synthesis, Crystal Structures, and DNA-Binding Properties of Cd(Ⅱ)/Fe(Ⅲ) Complexes with 4-Fluorophenyl-N-(quinolin-2-ylmethylene)thiosemicarbazide[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(9): 1790-1798. doi: 10.11862/CJIC.2022.176 shu

Synthesis, Crystal Structures, and DNA-Binding Properties of Cd(Ⅱ)/Fe(Ⅲ) Complexes with 4-Fluorophenyl-N-(quinolin-2-ylmethylene)thiosemicarbazide

Xiao-Hong LI ¹ ,
Xian-Wei WU ^2,, ,
Yuan WANG ¹ ,
Wei-Na WU ^1,,

1.
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, Henan 454000, China
2.
Department of Environmental Art and Design, School of Architectural and Artistic, Henan Polytechnic University, Jiaozuo, Henan 454000, China

Corresponding author: Xian-Wei WU, wxw0533@126.com Wei-Na WU, wuwn08@hpu.edu.cn
Received Date: 12 July 2021
Revised Date: 18 July 2022

Figures(6)

Two complexes [Cd₂(L)₂(NO₃)₂] (1) and [Fe(L)₂]NO₃·3CH₃OH (2), as well as (H₂L)NO₃ (HL=4-fluorophenyl-N-(quinolin-2-ylmethylene)thiosemicarbazide) have been synthesized and structurally determined by single-crystal X-ray diffraction, elemental analysis, and IR. The results show that 1 is a centrosymmetry binuclear complex, in which each central Cd(Ⅱ) ion is coordinated by one independent anionic ligand L^- with a [N₂S] donor set, one bidentate nitrate anion, and another μ₂-bridged S atom from the adjacent thiosemicarbazone, thus providing a distorted octahedron geometry. The Fe(Ⅲ) ion in complex 2 displays the same coordination geometry as the Cd(Ⅱ) ion in 1, while is surrounded by two tridentate L^- ligands. The fluorescence spectra, the absorption spectra, and the viscosity measurements indicate that complex 2 could effectively bind with ct-DNA through intercalation mode, while HL and complex 1 might interact with ct-DNA by outside groove binding mode, and the binding affinity of complex 2 with ct-DNA was stronger than those of HL and complex 1. In addition, the results of cytotoxicity experiments showed that complex 2 had the strongest ability to inhibit the proliferation of HeLa tumor cells among the three compounds.
- quinoline,
- thiosemicarbazone,
- complex,
- crystal structure,
- DNA interaction
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