Citation: Li-Ping ZHANG, Yong-Gang WAN, Yan-Min WU, Jie WANG, Dong-Bin XU, Jian-Lei XUE, Wen-Bo DUAN, Dao-Sen LIU. One-Pot Aqueous Synthesis and Cell Labeling Application of Glutathione Capped Cu-In-Zn-S Quantum Dots[J]. Chinese Journal of Inorganic Chemistry, ;2022, 38(2): 361-367. doi: 10.11862/CJIC.2022.003 shu

One-Pot Aqueous Synthesis and Cell Labeling Application of Glutathione Capped Cu-In-Zn-S Quantum Dots

1.
College of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China
2.
Communication and Electronic Engineering Institute, Qiqihar University, Qiqihar, Heilongjiang 161006, China

Corresponding author: Li-Ping ZHANG, zhangliping@qmu.edu.cn
Received Date: 11 June 2021
Revised Date: 27 September 2021

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We report a one-pot method to directly synthesize highly luminescent Cu-n-Zn-S (CIZS) quantum dots (QDs) in aqueous media by using bio-compatible glutathione (GSH) as capping ligand and stabilizer. The influences of various experimental variables, including reaction time, pH value, and precursor ratio, have been systematically investigated. The optical features and structure of the obtained CIZS QDs have been characterized by UV-Vis and fluorescence spectroscopy, transmission electron microscope, powder X-ray diffraction, and FT-IR. As a result, the stable GSH capped CIZS QDs exhibited excellent photoluminescence emission properties, narrow size distribution and excellent biocompatibility under optimum experimental conditions. In addition, as-prepared CIZS QDs were successfully used for fluorescence imaging of MDA-MB-231 cells and emitted bright red fluorescence.
- hydrophilic synthesis,
- Cu-In-Zn-S quantum dots,
- glutathione capped,
- photoluminescence
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沈阳化工大学材料科学与工程学院沈阳 110142