Citation: Zi-Liang ZHENG, Bo-Tao QU, Xiao-Rong YANG, Ling LIU, Rui-Ping ZHANG. Tumor-Targeted Pt-Cu Nanoplatform for Photothermal Therapy Guided by the Second Near-Infrared Window Photoacoustic Imaging[J]. Chinese Journal of Inorganic Chemistry, ;2021, 37(11): 1991-2001. doi: 10.11862/CJIC.2021.238 shu

Tumor-Targeted Pt-Cu Nanoplatform for Photothermal Therapy Guided by the Second Near-Infrared Window Photoacoustic Imaging

Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, China

Corresponding author: Rui-Ping ZHANG, zrp_7142@sxmu.edu.cn
Received Date: 18 April 2021
Revised Date: 2 September 2021

Figures(7)

A nanoplatform Pt-Cu@PLL@HA based on PtCu nano-alloys encapsulated in the positively charged polylysine (PLL) and negatively charged hyaluronic acid (HA) was constructed via layer-by-layer (LBL) self-assem-bly technology. HA not only prolonged the blood circulation time of Pt-Cu@PLL@HA, but also realized the active tumor targeting and enhanced its high accumulation in tumor region. After fast HA degradation in response to hyaluronidase (HAase) in the tumor microenvironment, the site-specific exposure of Pt-Cu@PLL(+) was conducive to the uptake of tumor cells. Owing to the strong NIR-Ⅱ (the second near-infrared window) absorption capability of Pt-Cu alloy, the effective photothermal tumor ablation could be realized by the precise guidance of NIR-Ⅱ photoacoustic imaging.
- the second near-infrared window,
- photothermal therapy,
- photoacoustic imaging,
- Pt-Cu alloy,
- layer-by-layer self-assembly
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