Citation: GAO Chun-Yan, QIAO Pei-Pei, YANG Huang-Ze, ZHANG Peng-Fei, LEI Yun-Bo, ZHANG Yong-Po, WANG Min, YUE Ai-Qin, ZHAO Jin-Zhong, DU Wei-Jun. Synthesis, Structure, DNA interaction and Cytotoxicity of Pyridine-Based Mononuclear Cobalt(Ⅱ) Complex[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(9): 1783-1790. doi: 10.11862/CJIC.2020.208 shu

Synthesis, Structure, DNA interaction and Cytotoxicity of Pyridine-Based Mononuclear Cobalt(Ⅱ) Complex

1.
Department of Basic Sciences, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China
2.
College of Agronomy, Shanxi Agricultural University, Jinzhong, Shanxi 030801, China

Corresponding author: GAO Chun-Yan, gaocynk@163.com DU Wei-Jun, duweijun68@126.com
Received Date: 7 March 2020
Revised Date: 27 May 2020

Figures(6)

A new mononuclear complex[Co(L)Cl₂] (L=4-methyl-N, N-bis(pyridin-2-ylmethyl) aniline) was synthesized and characterized by infrared spectroscopy, elemental analysis and X-ray single crystal diffraction. The results show that the Co(Ⅱ) center of the complex is a distorted trigonal-bipyramidal configuration with N₃Cl₂ donor sets. The interaction between the complex and DNA was studied by the electron absorption, emission spectroscopy and gel electrophoresis. The results reveal that the complex bind to CT-DNA by partial intercalation binding mode, and in the presence of hydrogen peroxide as a inducer, the DNA cleavage abilities of the complex are significantly improved. The Oxidative mechanism has been demonstrated via the pathway involving both hydroxyl radicals (·OH) and singlet oxygen (¹O₂) as ROS, and the binding site between the complex and DNA may be in the large groove. In addition, in vitro cytotoxicity of the drug has been tested by MTT against HeLa, BGC-823 and NCI-H460 cell lines.
- cobalt(Ⅱ) complex,
- pyridine-based ligand,
- DNA binding,
- DNA cleavage,
- cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142