Citation: WU Jian, TAO Qin, GE Chao, XUE Xu-Ling, QIAN Yong, LIU Hong-Ke. Synthesis and Antitumor Properties of Ruthenium-Arene Complexes Based on Natural Product Perillol[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(7): 1223-1232. doi: 10.11862/CJIC.2020.159 shu

Synthesis and Antitumor Properties of Ruthenium-Arene Complexes Based on Natural Product Perillol

School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China

Corresponding author: XUE Xu-Ling, xuexuling87@163.com LIU Hong-Ke, liuhongke@njnu.edu.cn
Received Date: 4 December 2019
Revised Date: 16 May 2020

Figures(8)

As one of the few natural products that is useful both in the prevention and treatment of cancers, perillol has been used as a clinical drug for the treatment of cancer. However, perillol has low bioavailability and large dosage by oral administration, which limits its clinical application. In this work, perillol was chemically modified and introduced into the metal-arene complex as a ligand, thus a novel ruthenium-arene complex Ru-L was synthesized and characterized by NMR, ESI-MS and elemental analysis. The complex exhibited high cytotoxic activity against several tumor cells A2780, A2780/DDP and MCF-7, while it was none toxic to the normal cell lines (IC₅₀>200 μmol·L^-1). Absorbance and fluorescence spectra suggested that the complex had a fast hydrolysis rate, could bind to CTDNA with a high affinity through intercalation mode and interact with BSA/HSA by static quenching. Flow cytometry also revealed that the complex induced tumor cell cycle arrest in the G0/G1 phase, which led to apoptosis of tumor cells. The above results indicate that the ruthenium-arene complex Ru-L based on perillol can overcome the disadvantages of perillyl alcohol, such as its high doses and severe toxicity.
- natural products,
- metal-arene complex,
- perillol,
- anticancer
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