Citation: WANG Zhi-Min, HU Ming, XING Ben-Gang. Application of Near-Infrared Upconversion Nanotransducers in Optogenetic Regulation[J]. Chinese Journal of Inorganic Chemistry, ;2020, 36(6): 969-982. doi: 10.11862/CJIC.2020.122 shu

Application of Near-Infrared Upconversion Nanotransducers in Optogenetic Regulation

Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore

Corresponding author: XING Ben-Gang, Bengang@ntu.edu.sg
Received Date: 13 February 2020
Revised Date: 6 April 2020

Figures(9)

As an emerging biotechnology optogenetics attracts tremendous attention in spatiotemporal control of biological functions, especially in neuronal excitability manipulation through channelrhodopsins (ChRs). However, it remains a major challenge for noninvasive deep-tissue applications due to current optogenetic tools are mainly visible light-sensitive. To address this issue, recent studies have utilized lanthanide-doped upconversion nanoparticles (UCNPs), as promising photo-nanotransducers that can convert near-infrared (NIR) light to visible emissions, thereby facilitating the optogenetic regulation in complex living systems. In this review, the development and advances in UCNPs-based optogentics are summarized in detail. In addition, future perspectives for advancing such a hybrid upconversion optogenetic technique into clinical research are proposed.
- optogenetics,
- upconversion nanoparticles,
- near-infrared nanotransducers,
- photo-regulation,
- ion channels,
- biological activity
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