Citation: CHEN Xuan, WANG Hua-Hua, Waseem Akram, SUN Yan-Mei, LIAO Yu-Hui, SI Li-Ping, LIU Hai-Yang, Chi-Kwong Chang. Tri-hydroxyl Corrole and Its Gallium(Ⅲ) Complex: DNA-Binding, Photocleavage and in Vitro Photodynamic Antitumor Activities[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(9): 1687-1697. doi: 10.11862/CJIC.2019.201 shu

Tri-hydroxyl Corrole and Its Gallium(Ⅲ) Complex: DNA-Binding, Photocleavage and in Vitro Photodynamic Antitumor Activities

1.
Department of Chemistry, Key Laboratory of Functional Molecular Engineering of Guangdong Province, South China University of Technology, Guangzhou 510641, China
2.
Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou 510091, China
3.
School of Materials Science and Energy Engineering, Foshan University, Foshan, Guangdong 528000, China
4.
Department of Chemistry, Michigan State University, E. Lansing, MI 48824, USA

Corresponding author: SI Li-Ping, chhyliu@scut.edu.cn LIU Hai-Yang, lipingsi@fosu.edu.cn
Received Date: 1 March 2019
Revised Date: 6 June 2019

Figures(12)

A new tri-hydroxyl corrole, 10-(4-hydroxyphenyl)-5, 15-bis(4-(2-hydroxyethyl) amino-2, 3, 5, 6-tetrafluoro-phenyl) corrole (1), and its gallium complex (1-Ga), were prepared. Interactions between these two corrole derivatives and calf thymus DNA were investigated by multiple spectroscopic methods, viscosity experiments and molecular docking simulation, which reveal that 1 and 1-Ga interact with calf thymus DNA via outside binding mode. Agarose gel electrophoretic experimental results demonstrated that 1 and 1-Ga exhibit excellent photonu-clease activity. Both compounds demonstrated high photocytotoxic activity against human lung cancer cells A549, hepatoma cell HepG2 and human breast cancer cell MCF-7. After light irradiation, they might induce HepG2 cells apoptosis via ROS-mediated mitochondrial pathways. Furthermore, 1-Ga could arrest the tumor cell cycle at G2/M phases.
- corrole,
- gallium,
- DNA-binding,
- photodynamic therapy,
- anti-tumor activity
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沈阳化工大学材料科学与工程学院沈阳 110142