Citation: LUO Bo, YU Hao-Tian, LIU Meng-Qin, ZHANG Fu-Xing, KUANG Dai-Zhi, TAN Yu-Xing, JIANG Wu-Jiu. Syntheses, Crystal Structures and Biological Activity of Dibenzyltin Complexes Based on Substituted Benzoyl Hydrazine-Pyruvic Acid[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(7): 1212-1220. doi: 10.11862/CJIC.2019.151 shu

Syntheses, Crystal Structures and Biological Activity of Dibenzyltin Complexes Based on Substituted Benzoyl Hydrazine-Pyruvic Acid

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province, Key Laboratory of Functional Organometallic Materials, University of Hunan Province, College of Chemistry and Material Science, Hengyang Normal University, Hengyang, Hunan 421008, China

Corresponding author: JIANG Wu-Jiu, jwj_china@163.com
Received Date: 23 February 2019
Revised Date: 23 April 2019

Figures(8)

Two benzyltin complexes has been synthesized via the reaction of substituted benzoyl hydrazine-pyruvic acid with dibenzyltin dichloride. The complexes C1 and C2 have been characterized by IR, ¹H NMR, ¹³C NMR ¹¹⁹Sn NMR spectra, elemental analysis, HRMS and the crystal structures have been determined by X-ray diffraction. Crystallographic data show that C1 forms a one-dimensional chain structure, C2 is a centrosymmetric dimer, and there is a Sn₂O₂ four-membered ring in the middle of the molecule. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines (H460, HepG2, MCF7). The interaction between complex C1 and calf thymus DNA were studied by EB fluorescent probe, and the ability of complex C1 to cleave plasmid DNA pBR322 was investigated by gel electrophoresis. The results show that the complexes C1 and C2 have good inhibitory effects on three kinds of cancer cells, but C1 is better than C2. The interaction of C1 with calf thymus DNA are intercalation, and it can effectively cleave DNA pBR322.
- organotin complex,
- hydrazone,
- synthesis,
- crystal structure,
- biological activity
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