Citation: LIU Rui-Xue, LAI De-Lin, DENG Qian-Jun, CHENG Feng-Jie, FAN Lan-Qiong, LIU Yan-Cheng. Synthesis, Crystal Structure and DNA Binding of Copper(Ⅱ) Complex of Penciclovir[J]. Chinese Journal of Inorganic Chemistry, ;2019, 35(1): 125-132. doi: 10.11862/CJIC.2019.013 shu

Synthesis, Crystal Structure and DNA Binding of Copper(Ⅱ) Complex of Penciclovir

1.
School of Chemistry and Pharmaceutical Sciences, State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin, Guangxi 541004, China
2.
School of Material Science and Energy Engineering, Foshan University, Foshan, Guangdong 528000, China

Corresponding author: DENG Qian-Jun, ycliu@gxnu.edu.cn LIU Yan-Cheng, 1192097240@qq.com
Received Date: 13 June 2018
Revised Date: 29 October 2018

Figures(6)

The first metal complex of the clinical antivirus agent, penciclovir (PCV), was synthesized and structurally characterized by IR, elemental analysis and X-ray single crystal diffraction analysis. In this complex, copper(Ⅱ) was selected as the bioactive metal center, which was coordinated by two PCV molecules to form a new copper(Ⅱ) complex of PCV, [Cu(PCV)₂(H₂O)₃]SO₄ (1). The in vitro antitumor activity of complex 1 towards a variety of typical human tumor cell lines has been explored. The results indicated that complex 1 showed enhanced antitumor activity comparing with PCV alone towards all the tested cell lines, in which the human hepatoma cell line BEL-7404 was the most sensitive one to complex 1 (Inhibition ratio (55.83±16.41)%). The inhibitory activity of complex 1 is more than 3 times that of PCV (Inhibition ratio (17.38±5.53)%). Furthermore, the DNA binding mechanism of complex 1 was also studied and discussed by means of UV-Vis absorption and fluorescence emission spectral analyses, as well as the DNA viscosity experiment. The results suggested that DNA, as the primary antitumor target, should be an important binding target of complex 1. And the classic intercalative binding mode might exist between complex 1 and CT-DNA.
- penciclovir,
- metal complex,
- copper (Ⅱ),
- antitumor activity,
- DNA binding
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沈阳化工大学材料科学与工程学院沈阳 110142