Citation: ZHANG Min-Zhi, WU Da-Ling, Shen Wei, ZHAO Guo-Liang. Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(12): 2227-2237. doi: 10.11862/CJIC.2018.271 shu

Syntheses, Crystal Structures and DNA-Binding of Transition Metal Complexes Constructed by 2-Methyl-4-thiazolecarboxylic Acid

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College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, Zhejiang 321004, China
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Xingzhi College, Zhejiang Normal University, Jinhua, Zhejiang 321004, China

Corresponding author: ZHAO Guo-Liang, sky53@zjnu.cn
Received Date: 5 June 2018
Revised Date: 28 September 2018

Figures(12)

Three novel transition metal complexes[Co(MTZA)₂(H₂O)₂]·3H₂O (1), [Cu(MTZA)₂(H₂O)]·2H₂O (2) and[Zn(MTZA)₂(H₂O)₂]·3H₂O (3) have been synthesized by using 2-methyl-4-thiazolecarboxylic acid (HMTZA, C₅H₅NO₂S), structurally confirmed by single crystal X-ray diffraction method, and characterized by elemental analysis, IR analysis and TG. The single crystal X-ray diffraction reveals that complex 1 crystallizes in monoclinic system with space group P2₁/n. Central Co²⁺ is six-coordinated to constitute a slightly distorted octahedral structure. Complex 2 crystallizes in triclinic system with space group P1, and its coordination number is five, forming a slightly distorted pentahedral coordination geometry. Complex 3 crystallizes in monoclinic system with space group P2₁/n. Each Zn²⁺ is six-coordinated to constitute a distorted octahedral geometry. In addition, DNA-binding of the ligand and complexes were also studied by EtBr fluorescence probe. The interactions of complexes with DNA were stronger than the ligand.
- 2-methyl-4-thiazolecarboxylic acid,
- transition metal complex,
- crystal structure,
- DNA-binding
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沈阳化工大学材料科学与工程学院沈阳 110142