Citation: WU Hao, WANG Yuan, SONG Yu-Fei, ZHANG Ling, WU Wei-Na. Syntheses, Crystal Structures and DNA-Binding Properties of Ni(Ⅱ)/Co(Ⅲ) Complexes with Pyrazine Thiosemicarbazone Ligand[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(11): 2057-2062. doi: 10.11862/CJIC.2018.253 shu

Syntheses, Crystal Structures and DNA-Binding Properties of Ni(Ⅱ)/Co(Ⅲ) Complexes with Pyrazine Thiosemicarbazone Ligand

College of Chemistry and Chemical Engineering, Henan Key Laboratory of Coal Green Conversion, Henan Polytechnic University, Jiaozuo, Henan 454000, China

Corresponding author: WANG Yuan, wangyuan08@hpu.edu.cn WU Wei-Na, wuwn08@hpu.edu.cn
Received Date: 13 June 2018
Revised Date: 24 August 2018

Figures(4)

Two complexes[Ni(L)(OAc)] (1) and[Co(L)₂]Cl·4CH₃OH (2) (HL=2-aceto-3-methylpyrazine N-(4-fluorophenyl)thiosemicarbazone) have been synthesized and structurally determined by single-crystal X-ray diffraction, elemental analysis and IR spectroscopy.X-ray diffraction analysis results show that the Ni(Ⅱ) ion in complex 1 with a distorted square planar geometry is surrounded by one anionic TSC ligand with NNS donor set and one monodentate acetate.By contrast, Co(Ⅲ) ion coordinates with two tridentate TSC ligands, and thus possessing a distorted octahedron coordination geometry.Moreover, the fluorescence spectra indicate that the interactions of complexes 1 and 2 with DNA are stronger than that of the ligand HL.
- Co(Ⅲ) complex,
- DNA-binding,
- Ni(Ⅱ) complex,
- pyrazine,
- thiosemicarbazone
1. [1]
  Rezaeivala M, Keypour H. Coord. Chem. Rev., 2014, 280:203-253 doi: 10.1016/j.ccr.2014.06.007
2. [2]
  Casanova I, Duran M L, Viqueira J, et al. Dalton Trans., 2018, 47:4325-4340 doi: 10.1039/C8DT00532J
3. [3]
  Qi J, Deng J, Qian K, et al. Eur. J. Med. Chem., 2017, 134:34-42 doi: 10.1016/j.ejmech.2017.04.009
4. [4]
  Qi J, Su L, Gou Y, et al. Eur. J. Med. Chem., 2015, 96:360-368 doi: 10.1016/j.ejmech.2015.04.031
5. [5]
  Zeglis B M, Divilov V, Lewis J S. J. Med. Chem., 2011, 54:2391-2398 doi: 10.1021/jm101532u
6. [6]
  Li M X, Zhang L Z, Yang M, et al. Bioorg. Med. Chem. Lett., 2012, 22:2418-2423 doi: 10.1016/j.bmcl.2012.02.024
7. [7]
  Li M X, Zhang L Z, Zhang D, et al. Eur. J. Med. Chem., 2011, 46:4383-4390 doi: 10.1016/j.ejmech.2011.07.009
8. [8]
  Li M X, Chen C L, Zhang D, et al. Eur. J. Med. Chem., 2010, 45:3169-3177 doi: 10.1016/j.ejmech.2010.04.009
9. [9]
  Rogolino D, Cavazzoni A, Gatti A, et al. Eur. J. Med. Chem., 2017, 128:140-153 doi: 10.1016/j.ejmech.2017.01.031
10. [10]
  Lovejoy D B, Sharp D M, Seebacher N, et al. J. Med. Chem., 2012, 55:7230-7244 doi: 10.1021/jm300768u
11. [11]
  Matesanz A I, Leitao I, Souza P. J. Inorg. Biochem., 2013, 125:26-31 doi: 10.1016/j.jinorgbio.2013.04.005
12. [12]
  Matesanz A I, Souza P. Inorg. Chem. Commun., 2013, 27:5-8 doi: 10.1016/j.inoche.2012.10.022
13. [13]
  MAO Pan-Dong, ZHAO Xiao-Lei, SHAO Zhi-Peng, et al. Chinese J. Inorg. Chem., 2017, 33:890-896 doi: 10.11862/CJIC.2017.109
14. [14]
  Sheldrick G M.SADABS, University of G?ttingen, Germany, 1996.
15. [15]
  Sheldrick G M.SHELX-97, Program for the Solution and the Refinement of Crystal Structures, University of G?ttingen, Germany, 1997.
16. [16]
  Ramachandran E, Thomas S P, Poornima P, et al. Eur. J. Med. Chem., 2012, 50:405-415 doi: 10.1016/j.ejmech.2012.02.026
17. [17]
  MAO Pan-Dong, YAN Ling-Ling, WANG Wen-Jing, et al. Chinese J. Inorg. Chem., 2016, 32:555-560 doi: 10.11862/CJIC.2016.064
18. [18]
  Nakamoto K. Infrared and Raman Spectra of Inorganic and Coordination Compounds.4th Ed. New York:Wiley, 1986:257
19. [19]
  MAO Pan-Dong, HAN Xue-Feng, WU Wei-Na, et al. Chinese J. Inorg. Chem., 2016, 32:161-166
20. [20]
  Yang Z Y, Wang Y, Wang Y. Bioorg. Med. Chem. Lett., 2007, 17:2096-2101 doi: 10.1016/j.bmcl.2006.10.049
1. [1]
  Zhaodong WANG . In situ synthesis, crystal structure, and magnetic characterization of a trinuclear copper complex based on a multi-substituted imidazo[1,5-a]pyrazine scaffold. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 597-604. doi: 10.11862/CJIC.20240268
2. [2]
  Yuxin CHEN , Yanni LING , Yuqing YAO , Keyi WANG , Linna LI , Xin ZHANG , Qin WANG , Hongdao LI , Wenmin WANG . Construction, structures, and interaction with DNA of two Sm^Ⅲ₄ complexes. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1141-1150. doi: 10.11862/CJIC.20240258
3. [3]
  Changqing MIAO , Fengjiao CHEN , Wenyu LI , Shujie WEI , Yuqing YAO , Keyi WANG , Ni WANG , Xiaoyan XIN , Ming FANG . Crystal structures, DNA action, and antibacterial activities of three tetranuclear lanthanide-based complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2455-2465. doi: 10.11862/CJIC.20240192
4. [4]
  Jingwen Zhao , Jianpu Tang , Zhen Cui , Limin Liu , Dayong Yang , Chi Yao . A DNA micro-complex containing polyaptamer for exosome separation and wound healing. Chinese Chemical Letters, 2024, 35(9): 109303-. doi: 10.1016/j.cclet.2023.109303
5. [5]
  Xiaofen GUAN , Yating LIU , Jia LI , Yiwen HU , Haiyuan DING , Yuanjing SHI , Zhiqiang WANG , Wenmin WANG . Synthesis, crystal structure, and DNA-binding of binuclear lanthanide complexes based on a multidentate Schiff base ligand. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2486-2496. doi: 10.11862/CJIC.20240122
6. [6]
  Haitang WANG , Yanni LING , Xiaqing MA , Yuxin CHEN , Rui ZHANG , Keyi WANG , Ying ZHANG , Wenmin WANG . Construction, crystal structures, and biological activities of two Ln^Ⅲ₃ complexes. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1474-1482. doi: 10.11862/CJIC.20240188
7. [7]
  Chao Ma , Cong Lin , Jian Li . MicroED as a powerful technique for the structure determination of complex porous materials. Chinese Journal of Structural Chemistry, 2024, 43(3): 100209-100209. doi: 10.1016/j.cjsc.2023.100209
8. [8]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
9. [9]
  Yuanjin Chen , Xianghui Shi , Dajiang Huang , Junnian Wei , Zhenfeng Xi . Synthesis and reactivity of cobalt dinitrogen complex supported by nonsymmetrical pincer ligand. Chinese Chemical Letters, 2024, 35(7): 109292-. doi: 10.1016/j.cclet.2023.109292
10. [10]
  Peng Meng , Qian-Cheng Luo , Aidan Brock , Xiaodong Wang , Mahboobeh Shahbazi , Aaron Micallef , John McMurtrie , Dongchen Qi , Yan-Zhen Zheng , Jingsan Xu . Molar ratio induced crystal transformation from coordination complex to coordination polymers. Chinese Chemical Letters, 2024, 35(4): 108542-. doi: 10.1016/j.cclet.2023.108542
11. [11]
  Ya-Ping Liu , Zhi-Rong Gui , Zhen-Wen Zhang , Sai-Kang Wang , Wei Lang , Yanzhu Liu , Qian-Yong Cao . A phenylphenthiazide anchored Tb(Ⅲ)-cyclen complex for fluorescent turn-on sensing of ClO⁻. Chinese Chemical Letters, 2025, 36(2): 109769-. doi: 10.1016/j.cclet.2024.109769
12. [12]
  Minghui Zhang , Na Zhang , Qian Zhao , Chao Wang , Alexander Steiner , Jianliang Xiao , Weijun Tang . Cobalt pincer complex-catalyzed highly enantioselective hydrogenation of quinoxalines. Chinese Chemical Letters, 2025, 36(4): 110081-. doi: 10.1016/j.cclet.2024.110081
13. [13]
  Yingying Yan , Wanhe Jia , Rui Cai , Chun Liu . An AIPE-active fluorinated cationic Pt(Ⅱ) complex for efficient detection of picric acid in aqueous media. Chinese Chemical Letters, 2024, 35(5): 108819-. doi: 10.1016/j.cclet.2023.108819
14. [14]
  Jian Peng , Yue Jiang , Shuangyu Wu , Yanran Cheng , Jingyu Liang , Yixin Wang , Zhuo Li , Sijie Lin . A nonradical oxidation process initiated by Ti-peroxo complex showed high specificity toward the degradation of tetracycline antibiotics. Chinese Chemical Letters, 2024, 35(5): 108903-. doi: 10.1016/j.cclet.2023.108903
15. [15]
  Wenjuan Jin , Zelong Chen , Yi Wang , Jiaxuan Li , Jiahui Li , Yuxin Pei , Zhichao Pei . Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy. Chinese Chemical Letters, 2024, 35(7): 109328-. doi: 10.1016/j.cclet.2023.109328
16. [16]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
17. [17]
  Zhengyi Shi , Jie Yin , Yang Xiao , Zhangrong Hou , Fei Song , Jianping Wang , Qingyi Tong , Changxing Qi , Yonghui Zhang . Unprecedented sesquiterpene-polycyclic polyprenylated acylphloroglucinol adduct against acute myeloid leukemia via inhibiting mitochondrial complex Ⅴ. Chinese Chemical Letters, 2024, 35(10): 109458-. doi: 10.1016/j.cclet.2023.109458
18. [18]
  Rong-Nan Yi , Wei-Min He . Electron donor-acceptor complex enabled arylation of dithiocarbamate anions with thianthrenium salts under aqueous micellar conditions. Chinese Chemical Letters, 2024, 35(11): 110194-. doi: 10.1016/j.cclet.2024.110194
19. [19]
  Bing Shen , Tongwei Yuan , Wenshuang Zhang , Yang Chen , Jiaqiang Xu . Complex shell Fe-ZnO derived from ZIF-8 as high-quality acetone MEMS sensor. Chinese Chemical Letters, 2024, 35(11): 109490-. doi: 10.1016/j.cclet.2024.109490
20. [20]
  Xiaoling WANG , Hongwu ZHANG , Daofu LIU . Synthesis, structure, and magnetic property of a cobalt(Ⅱ) complex based on pyridyl-substituted imino nitroxide radical. Chinese Journal of Inorganic Chemistry, 2025, 41(2): 407-412. doi: 10.11862/CJIC.20240214

Get Citation

PDF

XML

Metrics

PDF Downloads(4)
Abstract views(392)
HTML views(56)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142