Citation: GUO Da, XU Meng, SUN Xin-Yuan, OUYANG Jian-Ming. Syntheses, Characterization, Properties and Cytotoxicity of Hexagonal Calcium Oxalate Monohydrate Crystals with Various Sizes[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(10): 1883-1890. doi: 10.11862/CJIC.2018.212 shu

Syntheses, Characterization, Properties and Cytotoxicity of Hexagonal Calcium Oxalate Monohydrate Crystals with Various Sizes

Institute of Biomineralization and Lithiasis Research, Department of Chemistry, Jinan University, Guangzhou 510632, China

Corresponding author: OUYANG Jian-Ming, toyjm@jnu.edu.cn
Received Date: 12 May 2018
Revised Date: 12 June 2018

Figures(7)

Four kinds of calcium oxalate monohydrate (COM) crystals with the size of (1.5±0.4), (3.5±0.5), (5.5±0.5) and (9.5±1) μm respectively were synthesized by changing reaction temperature, solvent, additive and stirring speed. Their physiochemical properties were comparatively investigated. It is beneficial to obtain crystal with small size by adding additive Na₃Cit, increasing stirring speed, reducing reaction temperature or decreasing dielectric constant of the solvent. The results of X-ray diffraction revealed that all these crystals are single-phase COM crystals. With the increase of crystal size from 1 to 9 μm, COM crystals changed from rough blunt round to smooth thin sheet, the (101) crystal face of COM with high charge density increased, and both the charge density and the absolute value of ζ potential on crystal surface increased, leading an increase of the stability of crystal suspension. The cytotoxicity of these COM crystals to human kidney proximal tubular epithelial (HK-2) cells is negatively correlated with the crystal size.
- calcium oxalate monohydrate,
- size effect,
- crystal face,
- cytotoxicity
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