Citation: GAO An-Li, XIONG Qing-Feng, JIANG Jing, YU Juan, LOU Li-Guang, LIU Wei-Ping. Design, Syntheses and Anticancer Activities of Platinum(Ⅳ) Prodrugs with Dihydrogen Phosphate as an Axial Ligand[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(9): 1649-1654. doi: 10.11862/CJIC.2018.211 shu

Design, Syntheses and Anticancer Activities of Platinum(Ⅳ) Prodrugs with Dihydrogen Phosphate as an Axial Ligand

1.
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming 650106, China
2.
Tumor Pharmacology Lab, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

Corresponding author: JIANG Jing, dianaair@126.com LIU Wei-Ping, liuweiping1963@126.com
Received Date: 3 May 2018
Revised Date: 15 June 2018

Figures(5)

CPL-1501 and CPL-1504, two platinum(Ⅳ) prodrugs with dihydrogen phosphate as one axial ligand, were synthesized from cisplatin and oxaliplatin, respectively, as the starting material, and characterized by elemental analysis, IR as well as ¹³C and ³¹P NMR. Their reduction potential was measured via the cyclic voltammetry. The standard MTT was used to evaluate anticancer activity of the two prodrugs against several human cancer cell lines. CPL-1501 has a good water-solubility (10 mg·mL^-1) and water-stability. With the favorable E_p values, it can be readily reduced to an active prototype cisplatin in the oxygen-deprived micro-environment of cancer cells. The biological tests reveal that CPL-1501 is able to inhibit the growth of cancer cells and its anticancer activity is comparable to that of cisplatin but much greater than that of carboplatin, whereas CPL-1504 does not show significant activity, probably due to its lower E_p values.
- platinum(Ⅳ) complexes,
- synthesis,
- characterization,
- anticancer activity
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沈阳化工大学材料科学与工程学院沈阳 110142