Citation: LIU Shi-Chao, LIAN Xiao-Jie, XU Rui, SHI Zhen-Dong, DU Miao-Miao, ZHANG Si-Ruo, HE Zhi-Min, WEI Yan, HUANG Di, WANG Xiu-Mei, CUI Fu-Zai. Silk Nanofibers/Calcium Sulfate Composite: Preparation and Properties on Infective Bone Repair[J]. Chinese Journal of Inorganic Chemistry, ;2018, 34(3): 490-498. doi: 10.11862/CJIC.2018.065 shu

Silk Nanofibers/Calcium Sulfate Composite: Preparation and Properties on Infective Bone Repair

LIU Shi-Chao ¹ ,
LIAN Xiao-Jie ^1,2,, ,
XU Rui ¹ ,
SHI Zhen-Dong ^1,3 ,
DU Miao-Miao ¹ ,
ZHANG Si-Ruo ¹ ,
HE Zhi-Min ⁴ ,
WEI Yan ^1,2 ,
HUANG Di ^1,2 ,
WANG Xiu-Mei ⁵ ,
CUI Fu-Zai ⁵

1.
Department of Biomedical Engineering, Research Center for Nano-biomaterials & Regenerative Medicine, College of Mechanics, Taiyuan University of Technology, Taiyuan 030024, China
2.
Institute of Applied Mechanics & Biomedical Engineering, Shanxi Key Laboratory of Material Strength & Structural Impact, Taiyuan University of Technology, Taiyuan 030024, China
3.
National Demonstration Center for Experimental Mechanics Education, Taiyuan university of Technology, Taiyuan 030024, China
4.
Allgens Medical Science & Technology Co., Ltd., Beijing 100176, China
5.
Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China

Corresponding author: LIAN Xiao-Jie, yuhalian@126.com
Received Date: 30 September 2017
Revised Date: 30 November 2017

Figures(11)

Silk fibroin nanofibers solution (SFFs) was processed through controlling silk protein molecules self-assembly process, which were incorporated with vancomycin (VCM) to calcium sulfate (CS) for infective calcium sulfate-based materials. Surface morphology of the material was observed using SEM. Structure of the materials was studied with XRD. Drug release property of materials was evaluated using UV absorbance. Mechanical property of the materials was tested using computer-controlled electronic universal testing machine. Antibacterial property was illustrated by inhibition zone. Cytocompatibility was assessed by MTT assay. The results show that the addition of SFFs can not only effectively reduce the degradation rate of the composite material, but also enhance toughness and water resistance comparing to water as setting liquid. And the compressive strength first increased, then decreased as the concentration of SFFs from 0.017 5 to 2.1 mg·mL^-1. The results also show that the composite with controllable setting time has excellent antibacterial properties and drug slow-release performance in a week as well as better cell proliferation with MC-3T3.
- silk fibroin nanofibers,
- calcium sulfate hemihydrate,
- infective bone defect,
- mechanical properties,
- cytocompatibility
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