Citation: YUE Ai-Qin, ZHANG Yu-Ting, ZHANG Peng-Qian, GAO Yuan-Yuan, ZHANG Yong-Po, WANG Min, GAO Chun-Yan, ZHAO Jin-Zhong, DU Wei-Jun. Two Copper(Ⅱ) Complexes with dpa-Based Ligand:Syntheses, Structures, Nuclease Activity and Cytotoxicity[J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(12): 2287-2295. doi: 10.11862/CJIC.2017.273 shu

Two Copper(Ⅱ) Complexes with dpa-Based Ligand:Syntheses, Structures, Nuclease Activity and Cytotoxicity

1.
College of Agronomy, Shanxi Agricultural University, Taigu, Shanxi 030801, China
2.
College of Arts and Sciences, Shanxi Agricultural University, Taigu, Shanxi 030801, China
3.
Beijing Milu Ecological Research Center, Beijing 100076, China
4.
Chemical Engineering College, Inner Mongolia University of Technology, Hohhot 010051, China

Corresponding author: GAO Chun-Yan, gaocynk@163.com DU Wei-Jun, duweijun68@126.com
Received Date: 15 May 2017
Revised Date: 28 September 2017

Figures(5)

Two new mononuclear copper(Ⅱ) complexes, [CuL(NO₃)₂] (1) and[CuL(OAc)(H₂O)]ClO₄ (2), with dpa-based ligand (L=4-methyl-N, N-bis(pyridin-2-ylmethyl)aniline) have been synthesized and characterized by various physico-chemical techniques. The crystal structure of complex 1 displays a distorted pentagonal bipyramidal geometry, and the geometry around copper center of 2 can be described as a distorted octahedron. Interaction of the complexes with CT-DNA has been explored by using absorption and emission spectral methods, and the result suggests that the binding strength of the two complexes with DNA is a medium intercalative mode. The concentration-dependent and time-dependent DNA cleavage activity and the mechanism of DNA cleavage have been investigated, which suggest the DNA cleavage efficiencies of both complexes exhibit remarkable enhancement in the presence of external revulsants, and oxidative mechanism has been demonstrated via the pathway involving both hydroxyl radicals (·OH) and singlet oxygen (¹O₂) as ROS. The in vitro cytotoxic activity of the complexes has been examined by MTT on three cell lines such as HeLa, HepG-2 and SGC-7901.
- copper(Ⅱ) complexes,
- dpa-based ligand,
- DNA binding,
- DNA cleavage,
- cytotoxicity
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沈阳化工大学材料科学与工程学院沈阳 110142