Citation: CHEN Yan-Min, JIANG Yan, HONG Si-Yu, YAO Yong-Gang, XIE Qing-Fan. Two Adjustable Tetranuclear Copper(Ⅱ) Schiff Base Complexes: Self-Assembly, Crystal Structures and Antitumor Activities[J]. Chinese Journal of Inorganic Chemistry, ;2017, 33(6): 1023-1029. doi: 10.11862/CJIC.2017.122 shu

Two Adjustable Tetranuclear Copper(Ⅱ) Schiff Base Complexes: Self-Assembly, Crystal Structures and Antitumor Activities

College of Chemical Engineering and Material, Quanzhou Normal University, Quanzhou, Fujian 362000, China

Corresponding author: CHEN Yan-Min, zlmy@sina.com XIE Qing-Fan, rong516112@sina.cn
Received Date: 8 September 2016
Revised Date: 28 February 2017

Figures(7)

A tridentate Schiff base ligand (H₂Brsth), derived from the condensation of 5-bromosalicylaldehyde and 2-acetylthiophene, hydrothermally reacted with Cu(Ⅱ) acetate in mixed-solvent of ethanol and water to yield tetranuclear complexes [Cu₄(H₂O)₂(μ-Brsth)₂(μ₃-Brsth)₂] (1) and [Cu₄(H₂O)₂(Brsth)₂(μ-Brsth)₂(μ₂-4, 4'-bipy)₂] (2), which were characterized by elemental analyses, IR, electronic spectra, thermogravimetric analysis and single crystal X-ray diffraction. The X-ray diffraction analyses reveal that 1 crystallizes in the monoclinic space group P2₁/c with Z=2 while 2 in monoclinic space group C2/c with Z=4. In 1 and 2 each Cu(Ⅱ) atoms are five-coordinated with both distorted square pyramidal geometries. In 1 four Cu(Ⅱ) atoms are held together by four μ-O and/or μ₃-O type phenoxo oxygen atoms from four individual Schiff base ligands to form a chair-shaped {Cu₄O₄} unit. In 2 two pairs of Cu(Ⅱ) atoms join two μ₂-4, 4'-bipy molecules and two μ-phenoxo oxygen atoms from two Schiff base, respectively, to form a cyclic tetranuclear structure. The in vitro antitumor activities of ligand and complexes were tested by MTT method, which results show that the complexes have strong in vitro antitumor activity against HEPG2 cancer cells lines.CCDC: 1058056, 1; 1048382, 2.
- copper complex,
- Schiff base,
- crystal structure,
- antitumor activity
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