Citation: GAO Qi-Kuan, WANG Xi-Cun, SONG Yu-Min. Synthesis and Anticoagulant Properties of Water Soluble Nano-Oxides Fe₃O₄-Ferulic Acid Hybrid Material[J]. Chinese Journal of Inorganic Chemistry, ;2015, (12): 2365-2372. doi: 10.11862/CJIC.2015.301 shu

Synthesis and Anticoagulant Properties of Water Soluble Nano-Oxides Fe₃O₄-Ferulic Acid Hybrid Material

1.
1 Gansu Health Vocational College, Lanzhou 730000, China;
2.
2 College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China

Corresponding author: SONG Yu-Min,
Received Date: 25 June 2015
Available Online: 25 September 2015
Fund Project: 国家自然科学基金(No.21362031) (No.21362031)甘肃省教育厅(2015B-221)资助项目。 (2015B-221)

A hybrid materials of Fe₃O₄-DBI-PEG-ferulic acid (DBI=3,4-bihydroxy benzaldehyde, PEG= polyethylene glycol) were prepared by the method of grafting. The materials were characterized by IR, ¹H NMR, TG, SEM, TEM,VSM and particle size tests, which showed that the ferulic acid was grafted on the surface of Fe₃O₄ nano-oxides which was modified by DBI-PEG. Meanwhile, the hybrid materials are dissoluble in water (solubility> 10 mg·mL^-1)and with paramagnet. The anticoagulant properties of ferulic acid and the hybrid materials were tested by coagulation time (CT), recalcification time (RT), activated partial thromboplastin time (APTT), and prothrombin time (PT). The results indicated that the hybrid materials have better anticoagulant action than that of ferulic acid.
- ferulic acid;Fe₃O₄ nano-oxides;dissoluble;anticoagulant
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沈阳化工大学材料科学与工程学院沈阳 110142

Synthesis and Anticoagulant Properties of Water Soluble Nano-Oxides Fe3O4-Ferulic Acid Hybrid Material

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通讯作者: 陈斌, bchen63@163.com

Synthesis and Anticoagulant Properties of Water Soluble Nano-Oxides Fe₃O₄-Ferulic Acid Hybrid Material